Posts tagged network
“American Gut” sequencing project involving CU raises $340,000 online
Feb 7th
Known as the American Gut project, the effort raised the money through a crowdfunding effort online in which collective groups of people pool money to support various initiatives, said CU-Boulder Associate Professor Rob Knight of the BioFrontiers Institute. The $340,477 raised for the American Gut project is the largest amount of money ever raised through crowdfunding for a science project, said Knight, who is co-leading the effort with Jeff Leach, founder of the Human Food Project.
The money contributed by 2,005 funders will be used to sequence gut bacteria from about 3,500 people said Knight. Each human is believed to harbor roughly 10 trillion microorganisms — about 10 times more than the number of cells in the human body — that undertake a number of important functions ranging from digesting food to the strengthening of immune systems.
In 2009, a consortium of 200 researchers from 80 institutions organized by the National Institutes of Health, including Knight, mapped the normal microbial makeup of healthy humans as part of the $173 million Human Microbiome Project. Building on the massive NIH effort, the American Gut project will be an “open source” effort, meaning participants will have access to the data gathered to help understand how diet and lifestyle may contribute to human health through the interaction of our microbiomes, cells and genes, said Knight.
“The outpouring of public support for this research project demonstrates how public awareness of the role of our microbial systems in human health is growing,” said Knight, the project’s scientific lead who holds joint faculty appointments in CU-Boulder’s chemistry and biochemistry department and computer science department. “By looking at samples from the general public, we can get a far better sense of what a ‘normal’ microbiome is and what factors have the largest effects.”
The scientists are particularly interested in how diet and lifestyle, whether by choice or necessity, affect peoples’ microbial makeup, including those suffering from particular autoimmune diseases or who have food allergies, said Knight, also a Howard Hughes Medical Institute Early Career Scientist.
“The large number of participants in American Gut, coupled with our ongoing work in Africa and South America, will allow us to explore the impact of diet and lifestyle between western and more traditional societies,” said Leach. “We may find that our modern gut microbiome has shifted significantly away from our ancestral one, but reinstating some of that primal balance may be within our grasp.”
“I’m super excited about helping to build a system that not only integrates so much data but also presents it to the user in a useful way,” said Meg Pirrung, a graduate student in Knight’s lab. “This is an amazing opportunity for me and everyone involved.”
Daniel McDonald, a graduate student in the BioFrontiers Institute’s IQ Biology Program, said the American Gut project is allowing him to hone his interdisciplinary experience. IQ Biology students are involved in semester-long rotations that immerse them in disciplines ranging from mathematical and computational biology to biophysics and bio-imaging. “It’s an extraordinary opportunity for discovery,” he said.
The American Gut data also will also be used in the several IQ Biology Program courses taught by Knight with Manuel Lladser, an associate professor in the applied mathematics department. Last year the IQ Biology program at CU’s BioFrontiers Institute, which offers doctorates in eight disciplines, was awarded a $3 million grant from the National Science Foundation’s Integrative Graduate Education and Research Traineeship, or IGERT.
Second Genome, a biotech company headquartered in San Bruno, Calif., is working with the American Gut project to explore the connection between the human microbiome and type 2 diabetes, said company president and CEO Peter DiLaura.
“The American Gut project has succeeded in bringing together the largest citizen science network ever for human microbiome sample collection,” DiLaura said. “By building this extensive reference database, we now have the opportunity to explore the connections between the human microbiome and metabolic and inflammatory diseases.”
Although the first round of funding that enabled the project to commence has ended, a second phase also allows anyone in the world to join, said Leach. Once the scientific results are in from the initial group of participants, a third phase will allow new participants to obtain additional analyses crucial to understanding the microbiome.
“By integrating the tens of thousands of environmental samples that the scientific community has provided from around the world and applying powerful modeling approaches, we will be able to gain unprecedented insight into the links between our own microbes and those in our environment,” said Argonne National Laboratories microbial ecologist Jack Gilbert, a member of the Earth Microbiome Steering Committee.
“With advances in DNA sequencing, we are moving towards a world in which no infectious disease goes undiagnosed, and in which we have full knowledge of the microbes that inhabit us and our surroundings,” said Knight. “By participating in this project, thousands of people are helping us to make this future a reality.”
For more information on the American Gut project go to http://www.indiegogo.com/projects/american-gut. For more information on the BioFrontiers Institute go to http://biofrontiers.colorado.edu.
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Boulder County budget released
Dec 13th
The county’s mill levy and general operating budget to remain flat for 2013
Boulder County, Colo. – The Boulder County Commissioners have adopted a budget of $319.6 million for 2013, down from $321.7 million in 2012.
The 2013 budget represents a nearly flat comparison to the one adopted in 2012, based largely on the fact that the county is in its second year of a biannual property reappraisal cycle. With property values assessed only every other year, the second year in the cycle rarely reflects much of a change in the property tax portion of the county’s projected revenue stream.
The real difference in the budget this year is reflected through a reduction in carryover funds from the year prior and the annual adjustment of revenues in funds other than the General Fund (such as the Road & Bridge Fund and Capital Expenditure Fund) which fluctuate year-to-year based on their designated purpose and funding sources.
In keeping with a flat budget, the County Commissioners have worked hard to bring expenses in line with revenues for 2013, all the while continuing to support programs popular with county residents.
As in past years, the careful and deliberate process of evaluating program requests by elected offices and departments in a public forum has led to sound fiscal decisions that allow the county to function at a high level and continue to provide excellent service to county residents with essentially no increase to the General Fund.
“The 2013 budget is a culmination of more than six months of productive discussion and input from our non-profit leaders, elected officials and department heads who work closely every day with members of the public to figure out how best to meet the needs our community,” said Cindy Domenico, Chair of the Board of County Commissioners. “We are pleased to adopt this fully balanced budget which serves as a guiding document for carrying out the values of our residents.”
Commissioner Deb Gardner said she was pleased to adopt a budget that “balances the long and short term needs of the county and works within a sustainable context to make sure that the county will stay on track for years to come in responding to the priorities set forth by the residents of Boulder County.”
Commissioner Will Toor remarked on the complexity of the county budget and praised the efforts of county leaders and staff for continuing to implement and expand on highly-desired programs for residents, even within a fiscally-constrained framework.
“Whether we look at the strong support for our non-profit community and our human services safety net programs, or the extension of the popular EnergySmart program,” which faces an end to its federal grant in mid-2013, “or the continued improvement of our county’s transportation network, including all modes of transportation, we’re very pleased with the ability to support incremental expansions of these programs despite the fiscal constraints we’re under,” said Toor.
The County Commissioners thanked staff and everyone from the public who participated in the budget process, acknowledging that the collaborative effort in creating next year’s budget made for a much better document through their efforts.
Commissioners certify mill levy
The Commissioners also today certified a mill levy of 24.645 mills, the same as the last two years, which is projected to generate property tax revenues of $134,612,456 in 2013 (up only slightly from $134,408,021 in 2012). The county’s mill levy amount represents roughly 29 percent of a property owner’s total average property tax bill within Boulder County. Other taxing entities that receive property tax revenues include (from 2012 data): school districts (53%), cities and towns (11%), and “other” fire, water and special districts (7%).
For a copy of the funding package for 2013, visit: www.bouldercounty.org/gov/budget.
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