Posts tagged BioServe
Space flight to test antibiotic’s effectiveness
Jan 3rd
CU-Boulder to fly antibiotic experiment,
education project on ants to space station
education project on ants to space station
NASA Television will provide live coverage of the launch of Orbital Sciences Corp.’s commercial Cygnus spacecraft on Tuesday, Jan. 7 from NASA’s Wallops Flight Facility in Virginia, which will be carrying two University of Colorado Boulder payloads to the International Space Station.
The two CU-Boulder payloads — a biomedical antibiotic experiment and an educational K-12 experiment involving ant behavior in microgravity — are slated to be launched aboard Orbital Sciences Corp.’s Antares rocket at 11:55 a.m. MST. Both experiments were designed by BioServe Space Technologies, a NASA-funded center in CU-Boulder’s aerospace engineering sciences department.
The CU-Boulder biomedical experiment was designed to test the effectiveness of antibiotics in space. Past experiments by CU-Boulder and other institutions have shown bacterial susceptibility to antibiotics is significantly reduced during spaceflight, although the reason is not yet known, said CU-Boulder Associate Professor David Klaus, principal investigator on the project.
Klaus said the investigation will examine changes in the gene expression of the bacteria E. coli during exposure to different concentrations of antibiotics while in the microgravity environment of space. The hope is to locate particular genes that are key to resisting antibiotics, which could lead to improved testing on Earth as well as new drug targets or new approaches to understanding antibiotic resistance in certain diseases or infections, said Klaus.
“Previous studies carried out in microgravity have shown that bacteria are able to grow in what normally would be an inhibitory concentration of the antibiotic,” said Klaus. “This investigation is aimed at characterizing the genetic basis for this response in the weightless environment of space with the intent of applying any insight gained toward combating the increasing emergence of drug-resistant pathogens here on Earth.”
Co-investigators on the project include BioServe Director Louis Stodieck, a research professor in aerospace engineering, and Shawn Levy, a researcher at the HudsonAlpha Institute for Biotechnology in Huntsville, Ala. The research effort also involves CU-Boulder doctoral candidate Luis Zea.
Bacterial resistance to antibiotics kills 100,000 Americans every year and represents a roughly $20 billion expense to the U.S. government in excess health care costs, said Klaus. The experiments will be undertaken using spaceflight test tubes contained in the Commercial Generic Bioprocessing Apparatus, or CGBA, an automated, suitcase-sized incubator, all designed and built by BioServe.
The second experiment launching to ISS is known as Ants in Space, which examines foraging patterns based on the density of the common Pavement Ant, said BioServe Business Development Manager and Education Program Director Stefanie Countryman. “Past experiments by Professor Deborah Gordon, principal investigator on this project, have shown that some ant species have the ability to search areas collectively without individual communication. When ant densities are high, each ant thoroughly searches one small area in a circular, “random” walk, she said. When ant densities are low, each ant searches by walking in a relatively straight line, allowing it to cover more ground.
“Ants assess their own density at the rate at which they meet,” said Countryman, who said the eight individual ant habitats on ISS will be loaded with roughly 100 ants each. “The experiment examines whether in microgravity ants will use the rate at which they meet to assess density, and so use straighter paths in the larger habitat areas. The results will be compared to ground controls, which in this case will include ant habitats in hundreds of K-12 classrooms around the world.”
Countryman has previously directed BioServe K-12 education experiments involving the behavior of butterflies, ladybugs and spiders in space, reaching hundreds of thousands of students around the world in the past two decades. For the ant experiments, BioServe is partnering with the Baylor College of Medicine’s Center for Education Outreach, a longstanding BioServe partner that has developed the education curriculum guide for the experiment.
BioServe research partners on the ant project include Gordon of Stanford University and Associate Professor Michael Greene of the University of Colorado Denver. The experiment is sponsored by NASA’s National Lab Education Office as well as the Center for the Advancement of Science in Space, a nonprofit group headquartered in Cape Canaveral, Fla.
Teachers interested in participating in the ant experiments may contact Countryman at countrym@colorado.edu. More information on the project for teachers and students will be online beginning in mid-January at http://www.bioedonline.org.
The flight will be the first Cygnus resupply cargo mission launched to ISS by Orbital Sciences Corp. and follows the earlier, successful launch of a Cygnus demo flight to ISS that arrived at the orbiting station Oct. 22.
In the past 25 years, BioServe has designed, built and flown microgravity life science research experiments on more than 40 space missions. BioServe has a full suite of space flight hardware, both on ISS and on the ground, which supports its own research as well as research conducted by its customers and partners. Past BioServe partners include large and small pharmaceutical and biotechnology companies, universities and NASA-funded researchers.
For more information on BioServe visit http://www.colorado.edu/engineering/BioServe/index.html.
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CU Boulder sends high school students experiments into space
Sep 11th
Space experiments dreamed up by three teenage winners of an international contest that will be streamed live on YouTube from the International Space Station Sept. 13 were made flight-ready by a University of Colorado Boulder space center.
The two winning experiments — one of which tests the ability of spiders to learn how to catch prey in the low-gravity of space, and the other which investigates how nutrients and compounds affect virulent bacteria growth in space — were announced in March. The contest is sponsored by YouTube, Lenova and Space Adventures with the involvement of NASA, the European Space Agency and the Japanese Space Agency.
“We took the ideas of the two winning experiments and transformed them into actual experiments that could be conducted in space,” said Stefanie Countryman, the business manager and outreach coordinator for BioServe Space Technologies, a NASA-sponsored center located in CU-Boulder’s aerospace engineering sciences department. The CU team also manifested the payload on an unmanned Japanese HTV rocket, conducted safety verifications and trained the astronaut flight crew on using BioServe hardware aboard the International Space Station, or ISS, for the project.
The global initiative sponsoring the contest is a new program known as YouTube Space Lab. YouTube Space Lab is one component of YouTube for Schools, a program that allows educators to access YouTube’s broad library of educational content from inside their school network. The contest generated more than 2,000 entries.
The student winners are Amr Mohamed, 18, of Alexandria, Egypt, who developed the idea for the spider experiment, and Dorothy Chen and Sara Ma, both 16, of Troy, Mich., who created the idea for the bacteria study. BioServe completed all of the mission integration and operations work for the two experiments and hand-delivered the loaded space flight hardware to the Tanegashima National Space Flight Center in Japan for launch to ISS on July 21.
The live, 45-minute YouTube Space Lab program stream from ISS, slated for 8:30 a.m. MDT on Sept. 13 will be hosted by Bill Nye “The Science Guy” and will include Mohamed, Chen and Ma. The winning experiments — selected by a panel that included British theoretical physicist Stephen Hawking, two NASA administrators, European Space Agency and Japanese Space Agency astronauts and Cirque de Soleil founder Guy Laliberte — will be performed by NASA astronaut Sunita Williams.
Countryman, who also will be part of the YouTube Space Lab live stream as she describes the role of BioServe in the project to Nye, said she was surprised by the sophistication of some of the experiments entered in the contest. “Seeing the level of intellect, not only from the top two winners but from six regional winners, makes us feel confident in the next generation of scientists and engineers,” she said.
Countryman said BioServe worked closely with Paula Cushing at the Denver Museum of Nature and Science and MaryAnn Hamilton of the Butterfly Pavilion in Westminster, Colo., to obtain the jumping spiders and analyze their behavior. BioServe designed, developed and built the flight habitat for the spiders. Once aboard ISS, the habitat will be placed inside a BioServe-built device known as a Commercial Generic Bioprocessing Apparatus, or CGBA.
In addition, BioServe worked with AgraQuest in Davis, Calif., a company that manufactures and sells the bacteria strain B. subtilis, which will be used in the experiment by Chen and Ma. BioServe researchers worked with the students to design the experiment, which included 48 fluid processing devices carried in six Group Activation Packs built by BioServe and which have flown on dozens of space missions.
BioServe also developed an HD camera system to record high-resolution still images and HD video of the spider habitat, which included both the arachnids and their food, fruit flies, Countryman said. One of BioServe’s CGBA devices on board ISS is providing power for the lighting system of the spider habitat and thermal control for both experiments, said Countryman.
As part of the contest, 14- to 18-year-olds, either alone or in groups of up to three, submitted videos describing their experiments to YouTube. All experiments submitted to the contest had to involve either biology or physics. People tuned into the YouTube Space Lab event can vote for their favorite experiments, Countryman said.
“For decades, one of our major thrusts at CU-Boulder’s BioServe Space Technologies has been to provide educational opportunities for hundreds of thousands of K-12 students around the world,” said Countryman. “This has been another opportunity for us to work with students on space payloads, a unique project that we hope will help steer many students from around the world into careers in the sciences.”
BioServe is a nonprofit, NASA-funded center founded in 1987 at CU-Boulder to develop new or improved products through space life science research in partnership with industry, academia and government, said BioServe Director Louis Stodieck. Since 1991 BioServe has flown payloads on 40 NASA space shuttle microgravity missions and additional payloads on several Russian and Japanese space vehicles.
YouTube, a video-sharing website, is a subsidiary of Google. Lenovo, a global company headquartered in Morrisville, N.C., is the world’s third-largest PC maker. Space Adventures, headquartered in Vienna, Va., provides flights for private citizens into space, including trips to the ISS.
To watch the winning experiments being performed on ISS go to http://www.youtube.com/spacelab. For more information on BioServe visithttp://www.colorado.edu/engineering/BioServe/.
CU-BOULDER AND NASA’S SPACE SHUTTLE PROGRAM: TRIUMPHS AND TRAGEDIES
Jul 5th
When NASA’s 30-year-old space shuttle program is shuttered following the Atlantis mission in July, the University of Colorado Boulder will look back at a rich relationship filled with triumph and tragedy and look ahead to an evolving international program of government and private efforts that will send humans and cargo into orbit.
Of the 19 astronaut-affiliates from CU — 18 from CU-Boulder and one from University of Colorado Colorado Springs — 16 flew on a total of 40 NASA space shuttle missions. The two who flew the most shuttle missions were Jim Voss, (M.S. aerospace engineering, 1974) a current scholar in residence at CU-Boulder who flew five missions, as did CU alumna Marsha Ivins (B.S. aerospace engineering, 1973).
Vance Brand, a Longmont native with two CU-Boulder degrees (B.A. business 1953, B.S. aerospace, 1960), began his astronaut career with the Apollo program — he flew on the historic Apollo-Soyuz mission that brought together astronauts and cosmonauts in space in 1981 — and went on to command three space shuttle flights.
Two CU-Boulder astronaut-alumni died aboard space shuttles. In 1986, Ellison Onizuka (B.S., M.S. aerospace engineering, 1969), was killed when Challenger exploded 73 seconds after liftoff, an event witnessed by millions around the world. In 2003, Kalpana Chawla (Ph.D. aerospace engineering, 1988) perished when Columbia disintegrated over Texas during Earth re-entry.
CU-Boulder’s Air Force ROTC honors the two fallen astronauts annually on campus with a color guard and wreath-laying ceremony.
A celebrated university reunion in space occurred on Dec. 2, 1990, when Columbia blasted off with three CU astronaut-alums. Brand, the Columbia space shuttle commander, was joined by mission specialist John “Mike” Lounge (M.S. astrogeophysics, 1970) and payload specialist Sam Durrance (Ph.D., astrogeophysics 1980) as part of the seven-man crew on the ASTRO-1 mission. Toting four telescopes in the cargo bay, the shuttle mission was the first ever dedicated to astronomy.
In addition to its prominent role in the astronaut program, CU-Boulder has flown dozens of science payloads on NASA’s 135 space shuttle missions. BioServe Space Technologies, a NASA-funded center in the aerospace engineering sciences department, has launched experiments onboard space shuttles 39 times since 1991, using the low-gravity of Earth orbit as a testing ground for a variety of agricultural, biomedical and educational payloads.
BioServe has worked with industrial and academic partners on experiments ranging from bone loss mitigation and the development of new antibiotics to K-12 educational payloads involving butterflies and spiders that drew the participation of more than a million students around the world. BioServe personnel have trained dozens of astronauts to operate their experimental hardware in space, both on the shuttle and the International Space Station.
NASA space shuttles also toted two key instruments developed by teams led by CU-Boulder faculty for the Hubble Space Telescope. The launch of Hubble aboard Atlantis in 1990 included a high-resolution spectrograph designed and built by a team led by CU-Boulder retired Professor John “Jack” Brandt of the Laboratory for Atmospheric and Space Physics. The instrument broke down wavelengths of light emanating from distant celestial objects to determine their compositions, motions and temperatures to help astronomers understand the conditions of the early universe.
Fittingly, the final Hubble repair mission launched in 2009 included a $70 million instrument designed by a CU-Boulder team and constructed with the help of Boulder’s Ball Aerospace & Technologies Corp., which also built the high resolution spectrograph launched on Hubble in 1990. Known as the Cosmic Origins Spectrograph, the CU instrument is being used to probe the fossil record of gases in the early universe for clues to the formation and evolution of galaxies, stars and planets, according to principal investigator and CU-Boulder Professor James Green of the Center for Astrophysics and Space Astronomy.
In 1989, the space shuttle Atlantis carried NASA’s Galileo spacecraft into orbit, the first leg of a six-year journey to Jupiter and its moons. The science instruments included two CU-Boulder ultraviolet spectrographs designed and built by LASP at a cost of $3.5 million under the direction of retired Professor Charles Hord and which were used for research ranging from analyzing complex organic molecules in the Jovian system to documenting the activity of volcanoes on one of Jupiter’s moons, Io.
In 1991, Discovery launched the Upper Atmosphere Research Satellite carrying seven instruments, including an $8 million instrument called the Solar Stellar Irradiance Comparison Experiment, or SOLSTICE, designed and built by LASP. The satellite went on to make accurate measurements of the sun in the ultraviolet and far UV light for a full 11-year solar cycle, allowing scientists to better understand the effects of solar radiation on Earth’s atmosphere and climate, said SOLSTICE Mission Manager Tom Sparn.
CU-Boulder’s LASP also built and flew two space shuttle payloads — one in 1998 aboard Columbia and a second in 2001 on Endeavour — that allowed scientists and students to explore the gentle collisions of particles of dust in space. The experiment provided new insights into the fundamental processes thought to have helped form planetary rings and perhaps played a role in the earliest stages of planet formation.
In addition, a small satellite designed and built by a LASP team that was to be deployed from the Challenger space shuttle in 1986 to orbit Earth and observe Halley’s comet was lost during the tragic explosion.
CU also flew experiments targeting the mechanics of granular material three times on space shuttles — in 1996, 1997 and 2003. Led by civil, environmental and architectural engineering Professor Stein Sture, now CU-Boulder’s vice chancellor for research, and managed by LASP, the tests allowed scientists to observe the behavior and cohesiveness of granular materials in microgravity and have led to a better understanding of how Earth’s surface responds during earthquakes and landslides. The 2003 mission successfully returned data from the in-flight experiments, but the seven astronauts and experimental hardware were lost when Columbia disintegrated during re-entry.
CU-Boulder’s involvement with the space shuttle program also included three payloads designed, built and flown by students, primarily undergraduates, from the Colorado Space Grant Consortium headquartered in aerospace engineering sciences. The first payload, dubbed ESCAPE, and which flew on Discovery in 1993, measured the sun’s effects on Earth’s atmosphere using a spectrometer to record extreme UV solar radiation and a camera to photograph the sun. The effort included the participation of nearly 100 students, primarily undergraduates, over a two-year span.
ESCAPE-2, flown on Atlantis in 1994, was a follow-on version of the Escape 1 payload that probed how solar radiation affected Earth’s thermosphere, a portion of Earth’s upper atmosphere. The payload involved about 75 students, mostly undergraduates, said Colorado Space Grant Consortium Director Chris Koehler.
A third CU-Boulder student-built space shuttle payload known as DATA-CHASER, was a two-part experiment launched aboard Discovery in 1997. The payload included hardware to test advanced remote technologies, as well as instruments to measure the sun in far UV wavelengths. DATA-CHASER was designed and built and tested by dozens of CU-Boulder students, primarily undergraduates, over a three-year span.
So what’s on deck at CU-Boulder following the end of NASA’s space shuttle program, in terms of both manned and unmanned flight vehicles? Hardware and experiments developed by BioServe already are manifested on various international resupply vehicles traveling to the International Space Station as well as on U.S. spacecraft now under development, said BioServe Director Louis Stodieck.
In August 2010 CU-Boulder was one of nine institutions selected by the Federal Aviation Administration to participate in a newly formed Center of Excellence for Commercial Space Transportation. The center focuses on four major research areas: space launch operations and traffic management; launch vehicle systems; commercial human space flight; and space commerce, including law, insurance, policy and regulation. All are aimed at ensuring safe and efficient private human space flight for non-NASA missions, said aerospace engineering Professor Dave Klaus, who directs the new CU-Boulder center.
CU-Boulder also is involved in a research partnership with Sierra Nevada Corp. of Louisville, Colo., which is designing and building a manned spacecraft called the Dream Chaser intended to replace the space shuttle for transporting humans and cargo into low-Earth orbit. Sierra Nevada has received about $200 million in NASA contracts to design and build the vehicle, which will be launched vertically and can land on conventional runways.
As part of its collaboration, Sierra Nevada is funding a CU team led by Klaus to develop methods for evaluating safety and operational aspects of the spacecraft. Klaus’ lab has a mock-up cockpit section of the Dream Chaser being used to test the ergonomic layout for instrument displays and controls. The students on the project are being advised by CU-Boulder’s Voss — who also is a vice president at Sierra Nevada Corp. — and his colleague Joe Tanner, both of whom joined the CU-Boulder faculty after retiring as NASA astronauts.
CU-Boulder currently is housing a full-scale mock-up of the Dream Chaser based on an earlier design of the spacecraft, as well as a 15 percent scale model that was successfully flight tested by a team including Sierra Nevada engineers and CU aerospace engineering faculty and students in December 2010. The hope of Sierra Nevada and CU-Boulder is that the Dream Chaser will provide routine crew transportation to and from the International Space Station as NASA turns its focus to deep space exploration missions.
In December 1990, when the space shuttle Columbia launched, Commander Vance Brand took with him a 10,000-year-old Paleo-Indian spear point that had been discovered on Colorado’s eastern plains. One wonders what the thundering liftoff of a NASA space shuttle might have looked like through the eyes of the earliest Americans, and what the next 10,000 years holds for human exploration of space in the solar system and beyond.
For more information visit the “CU in Space” website at http://www.colorado.edu/news/reports/space/.
