Posts tagged CU
Buffs take USC, split in So Cal games
Feb 17th
LOS ANGELES – After playing a forgettable second half in a loss at UCLA on Thursday, Colorado responded with 40 solid minutes of basketball and an 83-74 victory over Southern California on Sunday night at the Galen Center. The Buffaloes (19-7, 8-5 Pac-12) finished with five players scoring in double-figures, led by Xavier Johnson with 20 points and Josh Scott with 17. CU is now 5-0 on the season when five players score 10 or more points in a game. USC (10-15, 1-11) was able to rally late and got as close as eight with 28.5 seconds remaining, but it would not be enough. The Buffs smothered the Trojans with defense, forcing 17 turnovers. USC was led by Byron Wesley, who finished with 21 points and 8 rebounds. Johnson got the Buffs going offensively with five of his team’s first seven points. But two quick fouls put him on the bench.
Freshman Jaron Hopkins provided a spark from the bench with career-high 10 first-half points, including a three-pointer and a layup in transition that gave the Buffs a 10-point lead on two separate occasions. CU led by as many as 11 in the first half after Xavier Talton capped a 9-2 run with a trey, making the score 36-25 with 3:28 remaining in the half. The half ended with USC’s 12th turnover and CU on top 40-32; it was the third straight game in which the Buffs had scored 40 in a half, with 13 of those points coming off Trojan turnovers. CU picked up its fourth win in four games against USC in Pac-12 play. The Buffs are also perfect against Washington State (4-0) since joining the league in 2011. Colorado returns home for its final two home games against Arizona State on Wednesday (9 p.m. MT, ESPNU) and then No. 2 Arizona on Saturday, February 22 (7 p.m. MT, ESPN) when College GameDay will be in town for CU’s Senior Day.
CU: Stem cells boost aging muscles
Feb 16th
to new methods of mitigating muscle loss
New findings on why skeletal muscle stem cells stop dividing and renewing muscle mass during aging points up a unique therapeutic opportunity for managing muscle-wasting conditions in humans, says a new University of Colorado Boulder study.
According to CU-Boulder Professor Bradley Olwin, the loss of skeletal muscle mass and function as we age can lead to sarcopenia, a debilitating muscle-wasting condition that generally hits the elderly hardest. The new study indicates that altering two particular cell-signaling pathways independently in aged mice enhances muscle stem cell renewal and improves muscle regeneration.
One cell-signaling pathway the team identified, known as p38 MAPK, appears to be a major player in making or breaking the skeletal muscle stem cell, or satellite cell, renewal process in adult mice, said Olwin of the molecular, cellular and developmental biology department. Hyperactivation of the p38 MAPK cell-signaling pathway inhibits the renewal of muscle stem cells in aged mice, perhaps because of cellular stress and inflammatory responses acquired during the aging process.
The researchers knew that obliterating the p38 MAPK pathway in the stem cells of adult mice would block the renewal of satellite cells, said Olwin. But when the team only partially shut down the activity in the cell-signaling pathway by using a specific chemical inhibitor, the adult satellite cells showed significant renewal, he said. “We showed that the level of signaling from this cellular pathway is very important to the renewal of the satellite cells in adult mice, which was a very big surprise,” said Olwin.
A paper on the subject appeared online Feb. 16 in the journal Nature Medicine.
One reason the CU-Boulder study is important is that the results could lead to the use of low-dose inhibitors, perhaps anti-inflammatory compounds, to calm the activity in the p38 MAPK cell-signaling pathway in human muscle stem cells, said Olwin.
The CU-Boulder research team also identified a second cell-signaling pathway affecting skeletal muscle renewal – a receptor known as the fibroblast growth factor receptor-1, or FGFR-1. The researchers showed when the FGFR-1 receptor protein was turned on in specially bred lab mice, the renewal of satellite cells increased significantly. “We still don’t understand how that particular mechanism works,” he said.
Another major finding of the study was that while satellite cells transplanted from young mice to other young mice showed significant renewal for up to two years, those transplanted from old mice to young mice failed. “We found definitively that satellite cells from an aged mouse are not able to maintain the ability to replenish themselves,” Olwin said. “This is likely one of the contributors to loss of muscle mass during the aging process of humans.”
Co-authors included first author and CU-Boulder postdoctoral researcher Jennifer Bernet, former CU-Boulder graduate student John K. Hall, CU-Boulder undergraduate Thomas Carter, and CU-Boulder postdoctoral researchers Jason Doles and Kathleen Kelly-Tanaka. The National Institutes of Health and the Ellison Medical Foundation funded the study.
Olwin said skeletal muscle function and mass decline with age in humans beginning at roughly age 40. While there are a variety of muscle-wasting diseases — ranging from muscular dystrophy to Lou Gehrig’s disease — the condition known as sarcopenia can lead to severe muscle loss, frailty and eventual death and is leading to skyrocketing health care costs for the elderly. “If you live long enough, you’ll get it,” he said.
Olwin and his team worked closely on the research with a team from Stanford University led by Professor Helen Blau, which published a companion paper in the same issue of Nature Medicine. “We shared data with the Stanford team during the entire process and we all were very pleased with the study outcomes,” said Olwin. “This is how science should work.”
WBB: Swan and A-Wil weren’t enough to beat Huskies
Feb 15th
Husky’s backcourt unstoppable, but Buffs were in the game til the very end
BOULDER – Colorado’s Jamee Swan and Ashley Wilson hit career highpoints on Friday night, but a business-as-usual performance by Washington’s backcourt trumped them and the Buffaloes.
While Swan (25 points) and Wilson (15) were scoring career highs and Wilson was collecting her first career double-double with 10 rebounds, UW guards Kelsey Plum and Jazmine Davis were combining for 49 points to push the Huskies past the Buffs 87-80 at the Coors Events Center.
It wasn’t anything the Buffs hadn’t seen before – and they didn’t have many answers then either. In UW’s 81-71 Pac-12 Conference win last month in Seattle, they combined for 55 points, with Plum getting 35 and Davis 20.
On Friday night, Plum scored 25, Davis 24. They entered the game as the nation’s No. 2 top scoring backcourt, averaging 38.9 points.
“Washington’s two guards were outstanding . . . they torched us,” said CU coach Linda Lappe. “They pretty much did whatever they wanted to do . . . Davis carried them in first half (with 14 points), Plum came alive in the second (with 18). They were tough for us to guard.”
Still, even with Plum-Davis running mostly unchecked, the Buffs (14-10, 4-9) stayed in contention, cutting a 10-point Huskies lead to three twice in the final 1:16 but failing take the rally any further.
After tying the score at 60-60 on a Swan put-back with 8:57 remaining, a 10-0 run pushed UW ahead by 10 (70-60). CU first closed to within three (81-78) on Jen Reese’s first four points of the night, then got to within three again (83-80) on a basket by Arielle Roberson, who finished with 14 points and nine rebounds.
But three points back was as close as the Buffs would get, and Wilson said the game was lost by CU’s inability to “get those crucial stops, whether it was keeping them from scoring or getting a defensive rebound . . . It all comes down to the same thing: we make a push and tie the game and then we have a mental lapse where we don’t get that stop or defensive rebound. It’s been like that all conference season long.”
Lappe said scoring that many points – CU was averaging 70.2 – should have rewarded her team with a win: “Anytime we score 80, that has to be a game where we find a way to win. But it just didn’t go the right way tonight . . . you can’t give up 87 points; there are very few games that we will win that way. We just didn’t do what it took on the defensive side.”
Swann, whose previous career high was 20 against Stanford, said the Buffs lost focus late: “I think it comes down to who wants it more and it just happens that they want it a little more than us and we lose focus.”
UW coach Mike Neighbors didn’t seem surprised by Swan’s productivity. “She was on the scouting report because we recruited the heck out of that kid,” he said. “We wanted her very badly . . . she got it really going and we didn’t have a lot to answer – 25 points in 18 minutes . . . I’m just glad she had five fouls (No. 5 came with 1:30 left) or otherwise she could have had 50 (points).”
UW (14-10, 7-6) outscored CU 34-26 in the paint, outrebounded the Buffs 45-38 and converted 13 CU turnovers into 18 points. CU’s bench outscored UW’s 36-19 – mainly on Swan’s contribution before she fouled out with 1:30 to play. The Buffs hurt themselves at the free throw line, converting only 21 of 33 attempts. The Huskies shot 46.7 percent from the field (28-for-60), the Buffs 40.9 percent (27-for-66).
CU jumped to a 9-2 lead but UW recovered quickly with an 11-2 run and took its first lead on a Plum 3-pointer with 15:01 left before intermission. Davis followed with trey on the Huskies’ next possession, giving them their largest advantage (16-11) of the first half.
The first half’s last 13 minutes produced six ties and 11 lead changes before Ashley Wilson hit one of two free throws with 22.1 seconds left to put CU up 40-39 at the break.
The Huskies took a 49-43 to open the second half, getting back-to-back treys by Davis and Talia Walton, the latter hitting her triple with 16:38 left in the game. The Buffs fought back, closing to 51-50 on a 3-pointer by Lexy Kresl with just over 13 minutes remaining.
But the Huskies answered with a 6-0 run on consecutive conventional three-point plays by Plum and Chantel Osahor to open a seven-point advantage – 57-50 – with 12:19 to play.
If CU was to make a move, it would have to be soon. Ashley Wilson and Swan made two free throws each to pull the Buffs to within 57-54. After Swan scored consecutive baskets to tie the score at 60-60, the Huskies got 3-pointers from Osahor – only her second in five games – and Mercedes Wetmore and two free throws each from Katie Collier and Plum to pull ahead 70-60.
It was UW’s largest lead of the night, but a runner by Plum in the lane put CU behind 11 (75-64) just over a minute later. The Buffs pulled to within five (76-71) on a trey by Ashley Wilson, then seven (81-74) on a triple by Kresl with 1:16 left.
Reese got her first points of the night on a jumper to bring CU to 81-76 with 1:06 remaining, then hit a pair of free throws 3 seconds later to cut the deficit to 81-78. A layup by Roberson made it 83-80 but the Huskies closed it out with four free throws by Aminah Williams in the final 22 seconds.
“It took some warriors to win and I was so proud of our kids up and down the bench,” Neighbors said. “We get 19 (points) and 12 (rebounds) off of our bench tonight. There’s been games where we’ve gotten zero and zero.”
CU returns to the CEC on Sunday afternoon (1:30 p.m., Pac-12 Networks) to play Washington State.
Contact: BG.Brooks@Colorado.EDU