Posts tagged found
CU : Some good news for doggie lovers
Dec 11th
CU-Boulder, vet hospital team up for
clinical study to treat canine pain
clinical study to treat canine pain
A University of Colorado Boulder professor and her biomedical spinoff company Xalud Therapeutics Inc. of San Francisco are teaming up with a Front Range veterinarian to conduct a clinical study targeting an effective treatment for dogs suffering from chronic pain.
Distinguished Professor Linda Watkins of CU-Boulder’s psychology and neuroscience department said the study involves treating ailing dogs with a gene therapy using Interleukin-10, or IL-10, a protein and anti-inflammatory that both dogs and humans produce naturally. Watkins is working with veterinarian Robert Landry of Mountain Ridge Animal Hospital and Pain Management Center in Lafayette, who will be treating canine patients suffering from chronic and painful conditions, some of which already are being treated with various other medications with limited success.
Animals perceive and experience several levels of pain that are similar to humans, and chronic pain can be debilitating and also shorten the lives of pets, said Landry, one of only a handful of credentialed American Academy of Pain Management practitioners in Colorado. Landry currently is seeking Denver-Boulder area pet owners who have dogs suffering from chronic pain and who might be interested in participating in the study, which is free.
The new study is driven by research spearheaded by Watkins indicating a type of cell known as glial cells found in the nervous system of mammals plays a key role in pain. Under normal conditions, glial cells act as central nervous system “housekeepers,” cleaning up cellular debris and providing support for neurons, said Watkins. But glial cells also can play a pivotal role in pain enhancement by exciting neurons that both transmit pain signals and release a host of chemical compounds that cause problems like chronic neuropathic pain and other medical issues.
The team will use Xalud’s lead product candidate, XT-101, a gene therapy that harnesses the power of the potent anti-inflammatory IL-10 to normalize glial activity and eliminate neuropathic pain for up to 90 days with a single injection.
The gene therapy based on IL-10 has a number of advantages, including suppressing glial activity in the spinal cord, stimulating tissue regeneration and growth, decreasing the production of pro-inflammatory substances and increasing the production of anti-inflammatory substances, Watkins said. Landry and Watkins also have been working with the American Kennel Club on potential funding for additional clinical studies involving the treatment of chronic pain in dogs, said Watkins.
“We have already tested this new therapy in two pet dogs, and both have had remarkable reversals of their pain for long durations after a single injection of the therapeutic,” she said. “Our early peek at the potential of this therapeutic treatment in dogs shows essentially the same positive effects we have seen in laboratory rats used in our studies that have been treated with the therapy.”
Watkins said demonstrating the efficacy and safety of the new gene therapy in a second species of mammal is important in terms of moving it forward to eventually meet FDA regulations for human clinical trials.
In addition to studying what triggers glial cells to become activated and begin releasing pain-enhancing substances and ways to control chronic pain, Watkins and her research team recently discovered that clinically prescribed opioids also activate glial cells and cause them to release pain-enhancing substances. “Our ultimate goal is to find a means by which clinical pain control can be improved so as to relieve human suffering,” she said.
To contact Landry about possible participation in the study by family dogs suffering chronic pain and that might benefit from the experimental treatment, call the Mountain Ridge Animal Hospital at 303-665-4852.
For more information on CU-Boulder’s psychology and neuroscience department visit http://psych-www.colorado.edu/. For more information on Xalud Therapeutics Inc. visit http://www.xaludthera.com/. For more information on Mountain Ridge Animal Hospital visit http://www.mountainridgevet.com/.
[includeme src=”http://c1n.tv/boulder/media/bouldersponsors.html” frameborder=”0″ width=”670″ height=”300″]
–
CU Boulder research team finds massive crevasses and bendable ice affect stability of Antarctic ice shelf
Dec 7th
Gaping crevasses that penetrate upward from the bottom of the largest remaining ice shelf on the Antarctic Peninsula make it more susceptible to collapse, according to University of Colorado Boulder researchers who spent the last four Southern Hemisphere summers studying the massive floating sheet of ice that covers an area twice the size of Massachusetts.
But the scientists also found that ribbons running through the Larsen C Ice Shelf – made up of a mixture of ice types that, together, are more prone to bending than breaking – make the shelf more resilient than it otherwise would be.
The research team from CU-Boulder’s Cooperative Institute for Research in the Environmental Sciences presented the findings Dec. 6 at the American Geophysical Union’s annual meeting in San Francisco.
The Larsen C Ice Shelf is all that’s left of a series of ice shelves that once clung to the eastern edge of the Antarctic Peninsula and stretched into the Weddell Sea. When the other shelves disintegrated abruptly – including Larsen A in January 1995 and Larsen B in February 2002 – scientists were surprised by the speed of the breakup.
Researchers now believe that the catastrophic collapses of Larsen A and B were caused, at least in part, by rising temperatures in the region, where warming is increasing at six times the global average. The Antarctic Peninsula warmed 4.5 degrees Fahrenheit since the middle of the last century.
The warmer climate increased meltwater production, allowing more liquid to pool on top of the ice shelves. The water then drained into surface crevasses, wedging them open and cracking the shelf into individual icebergs, which resulted in rapid disintegration.
But while the meltwater may have been responsible for dealing the final blow to the shelves, researchers did not have the opportunity to study how the structure of the Larsen A and B shelves may have made them more vulnerable to drastic breakups – or protected the shelves from an even earlier demise.
CU-Boulder researchers did not want to miss the same opportunity on the Larsen C shelf, which covers more than 22,000 square miles of sea.
“It’s the perfect natural laboratory,” said Daniel McGrath, a doctoral student in the Department of Geography and part of the CIRES research team. “We wanted to study this shelf while it’s still stable in order to get a better understanding of the processes that affect ice shelf stability.”
McGrath worked with CIRES colleagues over the last four years to study the Larsen C shelf in order to better understand how the warming climate may have interacted with the shelf’s existing structure to increase its vulnerability to a catastrophic collapse.
McGrath presented two of the group’s key findings at the AGU meeting. The first was the role that long-existing crevasses that start at the base of the shelf and propagate upward – known as basal crevasses – play in making the shelf more vulnerable to disintegration. The second relates to the way a type of ice found in areas called suture zones may be protecting the shelf against a breakup.
The scientists used ground penetrating radar to map out the basal crevasses, which turn out to be massive. The yawning cracks can run for several miles in length and can penetrate upwards for more than 750 feet. While the basal crevasses have been a part of Larsen C for hundreds of years, the interaction between these features and a warming climate will likely make the shelf more susceptible to future disintegration. “They likely play a really important role in ice-shelf disintegration, both past and future,” McGrath said.
The research team also studied the impact of suture zones in the ice shelf. Larsen C is fed by 12 distinct glaciers, which dump a steady flow of thick ice into the shelf. But the promontories of land between the glacial outlets, where ice does not flow into the shelf, allow for the creation of ribbon-like suture zones, which knit the glacial inflows together and which turn out to be important to the ice shelf’s resilience. “The ice in these zones really holds the neighboring inflows together,” McGrath said.
The suture zones get their malleable characteristic from a combination of ice types. A key component of the suture zone mixture is formed when the bottoms of the 12 glacial inflows begin to melt. The resulting freshwater is more buoyant than the surrounding seawater, so it rises upward to the relatively thinner ice zones between the glacial inflows, where it refreezes on the underside of the shelf and contributes to the chaotic ice structure that makes suture zones more flexible than the surrounding ice.
It turns out that the resilient characteristics of the suture zones keep cracks, including the basal crevasses, from spreading across the ice shelf, even where the suture zone ice makes up a comparatively small amount of the total thickness of the shelf. The CIRES team found that at the shelf front, where the ice meets the open sea, suture zone ice constitutes only 20 percent of the total thickness of the shelf but was still able to limit the spread of rifts through the ice. “It’s a pretty small part of the total ice thickness, and yet, it still has this really important role of holding the ice shelf together,” McGrath said.
Other CU researchers involved in the Larsen C project were Konrad Steffen, former director of CIRES; Ted Scambos, of CIRES and CU-Boulder’s National Snow and Ice Data Center; Harihar Rajaram, of the Department of Civil Engineering; and Waleed Abdalati, of CIRES.
[includeme src=”http://c1n.tv/boulder/media/bouldersponsors.html” frameborder=”0″ width=”670″ height=”300″]
CU men get sweet revenge on No. 16 Baylor to advance into tourney championship
Nov 16th
By B.G. Brooks, Contributing Editor
CHARLESTON, S.C. – Revenge is sweet. Is payback sweeter? Doesn’t matter. The Colorado Buffaloes got both Friday afternoon in the Charleston Classic, holding off No. 16 Baylor 60-58 to advance to the tournament’s championship game.
CHARLESTON, S.C. – Revenge is sweet. Is payback sweeter? Doesn’t matter. The Colorado Buffaloes got both Friday afternoon in the Charleston Classic, holding off No. 16 Baylor 60-58 to advance to the tournament’s championship game.
The tournament takes a day off Saturday, with play resuming Sunday. The opponent is to be determined, but the Buffs will play for the championship at 6:30 p.m. MST (ESPN2) in the TD Arena.
CU reeled in a rare signature win in November, with its last defeat of a ranked team in non-conference play dating to 1973. Buffs coach Tad Boyle understood the magnitude of that as well as what it meant to defeat Baylor.
“In our first year (at CU), we’re up 10 at the half down there; we let one slip away,” a joyous Boyle said. “Last year in the NCAA Tournament we had another chance . . . it was a tie game with four or five minutes to go and we didn’t finish it off.
“That’s why I was so excited after the game – and that we had fans down here to support this team and program. I want them to know how much we appreciate it and all the people back home who couldn’t make the trip.”
CU’s last win against a ranked opponent came last March in the NCAA Tournament, when the Buffs defeated No. 23 UNLV. In the next game in Albuquerque, N.M, Baylor ousted the Buffs 80-63.
After Thursday’s 67-57 win against Dayton here, CU players were pointing at Baylor. They got their wish Friday – but making it come true wasn’t easy. On the game’s final play, Baylor’s 7-1 freshman, Isaiah Austin, caught a three-quarter length of the court rainbow pass, but missed at the buzzer.
“I held my breath,” said CU junior Andre Roberson. “I thought he was going to hit the shot. But he missed it luckily and we came out with the win.”
Added Buffs sophomore Askia Booker: “All kinds of things are running through your brain, but you try to stay positive with your teammates,” We’ve been here before, we’ve been in close games. We just had to fight through it and stay together and be positive.”
Booker led the Buffs with a career-high 19 points – 16 in the first half. Spencer Dinwiddie (11) was the only other CU player in double figures. Baylor (3-1) was led by Cory Jefferson’s 17, with Pierre Jackson adding 12.
CU made only four of 18 free throw attempts, including missing five of six in the final 1:01. The four makes were the fewest in a Buffs win since the 1980 team sank only two against Oklahoma in a 60-59 win. Fortunately on Friday, Booker hit one of two with 11.6 seconds to play, giving CU its narrow margin.
The Buffs (3-0) led four times in the first half, three of the advantages coming in the first 5 minutes and the first coming on a Dinwiddie trey (5-2). From there, CU’s challenge seemed to be staying close – and it was a challenge.
But Booker and the Buffs were up for it.
The long and athletic Bears twice led by five points in the first 20 minutes, with their second advantage coming on the heels of a controversial blocking call against Josh Scott. One official – the trio was from the Big 12 – whistled a charging foul on Pierre Jackson, but an outside official overruled it.
The officials huddled, the Buffs bench objected, but the call stood. Jackson hit one of two free throws, then added a three-pointer on the next Baylor possession, sending the Bears up 22-17.
CU – especially Booker – had loads of fight left. He tied the score at 22-22 with a trey at the about the 5 minute mark. After Baylor had crept ahead by three, Andre Roberson stepped back and drained a three-pointer to tie it again at 30-30.
Then it was “Ski Season” in South Carolina – at least for the first half’s final minute. With the shot clock ticking toward zero on CU’s next-to-last possession, Booker drained his second trey of the half to send the Buffs up 33-30.
When Baylor gave up the ball on the ensuing possession, the Buffs left the final 17 seconds wind down – with the ball in Booker’s hands. With two seconds showing, he pulled up just inside the three-point arc at the top of the key. His soft jumper nestled into the net and CU left the court with a 35-30 halftime lead.
Booker finished the half with a game-best 16 points on a career-high seven field goals and was the only player on either team in double figures. He called it “absolutely” the best half of his college career: “At this level, with this intensity, yeah it was.”
The Buffs outrebounded the Bears 22-17 – a Tad Boyle mandate – in the first and 41-40 for the game. Boyle called that “no easy task because they have some length and good athletes out there who are a little bit longer than ours and little more athletic at some positions. But our guys found a way and we overcame.”
CU gave up only three three-pointers to Baylor – a huge upgrade from their last meeting in March in the NCAA Tournament when the Bears’ Brady Heslip gunned down nine of 12 from beyond the arc for 27 points. In Friday’s first half, Heslip had two points and 0-for-3 from three-point range. He finished with seven points – and one trey.
Boyle’s biggest concern might have been his team’s first-half free throw shooting. After going only 14-of-24 from the line against Dayton, CU ended Friday’s first half one-for-six and finished the afternoon with 14 misses.
But the Buffs had other issues to open the second half, turning the ball over on two of their first four possessions and leaving Heslip open in transition. His first trey of the afternoon – and his only one of the game — brought the Bears to 37-35 in the first 3 minutes.
Baylor tied the score at 37-37 on a baby hook by Cory Jefferson, but Boyle and his bench believed Jefferson’s toss didn’t beat the shot clock. Whatever, the game was tied with 151/2 minutes to play and CU couldn’t allow Baylor to muster any more momentum.
At the 10-minute mark, the Bears took a 45-44 lead – their first since 30-27 – on a twisting drive and layup by Deuce Bello. The Buffs answered with a key trey from the left wing by Eli Stalzer and a goal tending call on a steal/layup by Sabatino Chen.
That four-point CU advantage (49-45) wilted fast. Baylor went inside and got immediate results from the 7-1 Austin and 6-8 Rico Gathers, who pulled the Bears within 50-49 with 7:30 remaining. But the Buffs stayed focused.
After Josh Scott scored on a goal tending call on Austin, Dinwiddie buried a three-pointer, sending the Buffs up 55-51. They hawked the ball on the Bears’ next possession, forcing a tie up that went to CU. Dinwiddie hit again, this time a two-pointer to give the Buffs their biggest lead at 57-51 with 3:40 to play.
But could they hold it? Yes, but with difficulty.
At the 3:00 mark, Baylor – trailing 57-52 – began pressing and extended its halfcourt defense. With 1:55 left, Jefferson hit a follow shot (57-54), Dinwiddie answered with a floating layup (59-54), Jackson countered with a jumper (59-56) and then added two free throws (59-58) with 19.8 seconds to play.
Dinwiddie missed the front end of a one-and-one, but Shane Harris-Tunks controlled the rebound. Booker was fouled with 11.6 seconds showing, hit the front end of his one-and-one (60-58) then missed the second.
Baylor rebounded, A.J. Walton drove the length of the court but couldn’t hit a difficult running shot from the right side. Roberson got the last of his 12 rebounds, was fouled and went to the free throw line. With 3.1 seconds left, he missed both attempts but in the scramble for the second miss, time nearly expired.
Baylor got possession with 0.2 remaining. Austin caught a lob pass just above the free throw line, turned, shot . . . and missed.
The Buffs had one sweet ‘W.’
“It’s revenge, it means a lot,” Booker said. “It burned last year in our hearts. Just knowing we could have this chance and we finally got it. We took full advantage of it. I loved it.”
[includeme src=”http://c1n.tv/boulder/media/bouldersponsors.html” frameborder=”0″ width=”670″ height=”300″]
