Posts tagged breaking
CU: Stem cells boost aging muscles
Feb 16th
to new methods of mitigating muscle loss
New findings on why skeletal muscle stem cells stop dividing and renewing muscle mass during aging points up a unique therapeutic opportunity for managing muscle-wasting conditions in humans, says a new University of Colorado Boulder study.
According to CU-Boulder Professor Bradley Olwin, the loss of skeletal muscle mass and function as we age can lead to sarcopenia, a debilitating muscle-wasting condition that generally hits the elderly hardest. The new study indicates that altering two particular cell-signaling pathways independently in aged mice enhances muscle stem cell renewal and improves muscle regeneration.
One cell-signaling pathway the team identified, known as p38 MAPK, appears to be a major player in making or breaking the skeletal muscle stem cell, or satellite cell, renewal process in adult mice, said Olwin of the molecular, cellular and developmental biology department. Hyperactivation of the p38 MAPK cell-signaling pathway inhibits the renewal of muscle stem cells in aged mice, perhaps because of cellular stress and inflammatory responses acquired during the aging process.
The researchers knew that obliterating the p38 MAPK pathway in the stem cells of adult mice would block the renewal of satellite cells, said Olwin. But when the team only partially shut down the activity in the cell-signaling pathway by using a specific chemical inhibitor, the adult satellite cells showed significant renewal, he said. “We showed that the level of signaling from this cellular pathway is very important to the renewal of the satellite cells in adult mice, which was a very big surprise,” said Olwin.
A paper on the subject appeared online Feb. 16 in the journal Nature Medicine.
One reason the CU-Boulder study is important is that the results could lead to the use of low-dose inhibitors, perhaps anti-inflammatory compounds, to calm the activity in the p38 MAPK cell-signaling pathway in human muscle stem cells, said Olwin.
The CU-Boulder research team also identified a second cell-signaling pathway affecting skeletal muscle renewal – a receptor known as the fibroblast growth factor receptor-1, or FGFR-1. The researchers showed when the FGFR-1 receptor protein was turned on in specially bred lab mice, the renewal of satellite cells increased significantly. “We still don’t understand how that particular mechanism works,” he said.
Another major finding of the study was that while satellite cells transplanted from young mice to other young mice showed significant renewal for up to two years, those transplanted from old mice to young mice failed. “We found definitively that satellite cells from an aged mouse are not able to maintain the ability to replenish themselves,” Olwin said. “This is likely one of the contributors to loss of muscle mass during the aging process of humans.”
Co-authors included first author and CU-Boulder postdoctoral researcher Jennifer Bernet, former CU-Boulder graduate student John K. Hall, CU-Boulder undergraduate Thomas Carter, and CU-Boulder postdoctoral researchers Jason Doles and Kathleen Kelly-Tanaka. The National Institutes of Health and the Ellison Medical Foundation funded the study.
Olwin said skeletal muscle function and mass decline with age in humans beginning at roughly age 40. While there are a variety of muscle-wasting diseases — ranging from muscular dystrophy to Lou Gehrig’s disease — the condition known as sarcopenia can lead to severe muscle loss, frailty and eventual death and is leading to skyrocketing health care costs for the elderly. “If you live long enough, you’ll get it,” he said.
Olwin and his team worked closely on the research with a team from Stanford University led by Professor Helen Blau, which published a companion paper in the same issue of Nature Medicine. “We shared data with the Stanford team during the entire process and we all were very pleased with the study outcomes,” said Olwin. “This is how science should work.”
ID thieves targeting vehicles, cops say
Feb 6th
Boulder police are reminding residents to lock their vehicle doors and to remember to take valuable items, such as purses and wallets, with them when leaving vehicles unattended.
The theft ring is believed to be involved in three cases in Boulder and more than 50 cases in other jurisdictions. So far, the thieves are responsible for approximately $100,000 in thefts. (Boulder police case numbers are: 14-1105, 14-1101 and 14-1475).
Investigators believe that at least two male suspects forcibly enter victim vehicles by breaking windows and then stealing purses and wallets, which were left in clearly visible areas of the cars. The suspects then deposit and cash the victim’s checks using the stolen IDs and often use wigs and other disguises when dealing with banks.
It’s believed the suspects are using newer-model SUVs when they make deposits at drive-up bank windows. Some of the vehicles used include a new, mint-green Ford Explorer with tinted windows; a white SUV and a black Infinity SUV.
Photos of suspects who appear to be females are attached and police are asking the public for help in identifying them. It’s possible that the suspects in the photos are wearing wigs or are otherwise disguised.
During the past two weeks, the suspects have trespassed vehicles and stolen IDs every single day somewhere in the Denver metro area.
Anyone with information about the crimes or the suspects is asked to call the Boulder Police Department at 303-441-3333 or to email us at BouldersMostWanted@bouldercolorado.gov. Those who have information but wish to remain anonymous may contact the Northern Colorado Crime Stoppers at 1-800-222-TIPS (8477) or 1-800-444-3776. Tips can also be submitted through the Crime Stoppers website at www.crimeshurt.com. Those submitting tips through Crime Stoppers that lead to the arrest and filing of charges on a suspect(s) may be eligible for a cash reward of up to $1,000 from Crime Stoppers.
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CU Frosh soccer phenom gets called to camp
Nov 27th
CARSON, Calif. – University of Colorado freshman phenom Brie Hooks was called into the U.S. Under-20 Women’s National Team training camp, which is running here from November 24 to December 1 at the U.S. Soccer National Training Center at the StubHub Center.
“We are excited that Brie has been called into this U-20 camp,” CU head coach Danny Sanchez said. “This opportunity is a byproduct of her play this fall, but also the team’s success. We know that she will represent herself and Colorado soccer well.”
Hooks stood out in her debut season at Colorado. In her first collegiate game, Hooks helped the Buffaloes to a 3-0 shutout of Northern Colorado behind a two-goal performance. Hooks is the first Buff in program history to score multiple goals in her Colorado debut. Hooks was an important part of the Buffs’ 1-0 victory over No. 15 Denver in the first round of the NCAA Women’s Soccer Championship, drawing the foul that set up the game-winning goal – Hooks and the Buffs ended their season with a trip to the Sweet 16, matching the program best finish first recorded in 2006.
In CU’s freshman offensive record books, Hooks concluded the season ranked third with eight goals and fourth with 18 points. Her 42 shots tie for eighth. Her eight goals also tie for eighth most in a single season at CU. Her four game-winning goals tie for fourth best in a single season at CU and tie for fourth best in Pac-12 Conference regular season play.
The training camp will serve as a bridge camp to an event in Florida in December, which will be the final preparation for the team before the Confederation of North, Central American and Caribbean Association Football Women’s U-20 Championship which will run from January 9-19 at the Truman Bodden Sports Complex in George Town, Cayman Islands.
The tournament features eight nations divided into two groups of four teams. The top two finishers in each group will qualify for the semifinals, with the winners of those games along with the winner of the third-place match earning berths to the 2014 FIFA U-20 Women’s World Cup, to be held in Canada. Players born on or after January 1, 1994 are age-eligible for the World Cup.
The USA is in Group A with Costa Rica, Jamaica and Guatemala, while Group B features the host Cayman Islands, Honduras, Trinidad & Tobago and Mexico.
The USA opens play on Thursday, Jan. 9 against Costa Rica, faces Jamaica on Saturday, Jan. 11 and finishes the group against Guatemala on Monday, Jan. 13. All three of the USA’s group games kick off at 5:30 p.m. MT. The semifinal matches will take place on Friday, Jan. 17 and the Championship and Third-Place matches are on Jan. 19.
Hooks joins the likes of Amy Barczuk and Nikki Marshall – record-breaking players at Colorado who turned their collegiate and national training camp success into professional careers. Barczuk was selected to the 2011 U.S. Women’s National Team Under-23 Training Camp and was a member of the U-23 player pool.
Marshall appeared in numerous training camps and tournaments as a member of the U.S. Women’s National Team U-23 player pool from 2009-11. With the U-20 team, Marshall helped the Americans to the silver medal at the 2007 Pan American Games and to the FIFIA U-20 Women’s World Cup Championship in 2008, where she was named the Sierra Mist Woman of the Match in the 2-1 championship win over North Korea.
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Marlee Horn Graduate Assistant SID University of Colorado