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CU team receives $9.2 million DOE grant to engineer E. coli into biofuels
Dec 4th
“This is a fantastic opportunity to take what we have worked on for the past decade to the next level,” said team leader Ryan Gill, a fellow of CU-Boulder’s Renewable and Sustainable Energy Institute, or RASEI. “In this project, we will develop technologies that are orders of magnitude beyond where we are currently.”
The team is working with a non-pathogenic strain of E. coli. Among the microbe’s more than 4,000 genes, the team is searching for a small set and how it can be manipulated in a combination of on and off states to change the bacteria’s behavior.
“E. coli is not going to want to make your biofuel at all,” said Gill, who’s also a CU-Boulder associate professor of chemical and biological engineering. “It doesn’t do that naturally. It’s programmed with thousands of genes controlling how it replicates. We’re figuring out what control structure we need to rewire in the bug to make it do what we want, not what it wants.”
Included in the team are Rob Knight, CU-Boulder associate professor of chemistry and biochemistry; Pin-Ching Maness, principal scientist at DOE’s National Renewable Energy Laboratory, or NREL; and Adam Arkin, physical biosciences director at DOE’s Lawrence Berkeley National Laboratory.
The researchers hope to engineer the production of ethylene and isobutanol in the modified E. coli. The two compounds are widely used commodities that can be converted into gasoline among other chemicals.
The greatest challenge is harnessing an efficient and inexpensive process that competes with abundant and low-cost fossil fuels like oil, according to Gill.
“Microorganisms and their genomes are incredibly complex machines,” said Gill. “The first step alone — of pinpointing the part of the E. coli genome that can help us make biofuels or other chemicals on a cost-competitive basis — is a daunting challenge. Then we have to determine if the results we want will take one year or decades, $5 million or $500 million.”
The team will be able to simultaneously identify numerous E. coli genes and the results of turning these genes on or off using advanced technologies. Many of the technologies have been developed by the researchers’ own labs.
The grant is the first of its kind from the DOE’s Office of Biological and Environmental Research and was awarded to only seven other research groups including teams led by MIT, Purdue University and the J. Craig Venter Institute.
In 2011, CU’s Technology Transfer Office named Gill an inventor of the year. In 2005, Gill won a National Science Foundation CAREER Award as well as a National Institutes of Health K25 Career Development Award for genomics research and teaching.
Sheriff Pelle Orders Fire Ban
Dec 3rd
On Monday, December 03, 2012 at 12:00 p.m., Sheriff Joe Pelle enacted a fire ban for;
The mountain corridor of Boulder County. The mountain corridor includes all unincorporated areas west of Highway 93 and Highway 36 (North and South Foothills Highways and Broadway Avenue in the City of Boulder) including Rabbit Mountain Open Space.
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CU Leeds School of Business: Positive, broad-based job growth forecast for Colorado in 2013
Dec 3rd
Wobbekind’s announcement is part of the 48th annual Colorado Business Economic Outlook Forum presented Dec. 3 by the Business Research Division of the Leeds School.
The comprehensive outlook for 2013 features forecasts and trends for 13 business sectors prepared by more than 100 key business, government and industry professionals.
“For the state, we see a very positive environment for 2013,” said Wobbekind, executive director of the Business Research Division. “We’re seeing a wide array of jobs being added and they’re diversifying our state economy.”
Overall, the forecast calls for a gain of 42,100 jobs in 2013, compared with a gain of about 47,900 jobs this year. All sectors of the Colorado economy are predicted to grow in 2013 with the exception of the information sector, which includes publishing and telecommunications.
When comparing the Leeds School forecast to employment outlooks for other states, Colorado is expected to be in the top 10 states for job growth in 2013 and perhaps in the top six or seven, according to Wobbekind.
Even with positive job growth projected for the state, Wobbekind said uncertainty from national and international factors will play a role in slowing growth during the first and second quarters of 2013. More momentum will occur in the second half of the year.
“Resolution of the so-called fiscal cliff and the resolution of the European debt crisis will have impacts on the national economy and that will filter down to the state level,” said Wobbekind. “Once that uncertainty gets resolved, we then expect business investments to start flowing again and consumers to start making decisions based on a known environment. We think the recovery will be quite a bit smoother after that.”
The strongest sector for projected job growth in Colorado in 2013 is the educational and health services sector. The sector is expected to add 7,600 jobs in 2013.
In addition, other leading growth sectors for 2013 include the professional and business services sector with 7,400 jobs added and leisure and hospitality with 5,000 workers added, mostly in the areas of accommodation and food services.
The trade, transportation and utilities sector is the largest provider of jobs in Colorado. It includes everything from wholesale and retail trade to a variety of transportation features such as the Denver International Airport and gas pipelines, as well as utilities. The sector is expected to grow 1.4 percent in 2013 with the addition of 5,600 jobs.
The construction sector is expected to grow by 6,300 jobs in 2013 — up from a 2,800-job increase this year — and produce $12.6 billion in total value of construction. While the biggest surprise in the sector is the demand for infrastructure work, the number of new multifamily units built is a contributing factor to the increase, among others.
Commenting on the overall forecast, Wobbekind said, “It’s great to be giving positive news to people year after year. Confidence levels nationally are at their highest levels in five years. We’re really starting to see a lot more optimism on the part of the average person on the street about the future.”
Colorado’s unemployment rate is expected to decrease from 8 percent in 2012 to 7.4 percent in 2013, which is comparatively better than the national unemployment rate.
Colorado’s population grew by 1.4 percent, or 71,000 people, in 2012 and is projected to increase by 1.5 percent, or 77,500 people, in 2013. Roughly half of the increase will derive from net migration, or the increase of people moving to the state.
To view the entire economic outlook for Colorado in 2013, including an overview of each of the state’s major economic sectors, visit http://leeds.colorado.edu/BRD and click on the Colorado Business Economic Outlook 2013 icon.