CU News
News from the University of Colorado in Boulder.

CU: Stem cells boost aging muscles
Feb 16th
to new methods of mitigating muscle loss
New findings on why skeletal muscle stem cells stop dividing and renewing muscle mass during aging points up a unique therapeutic opportunity for managing muscle-wasting conditions in humans, says a new University of Colorado Boulder study.
According to CU-Boulder Professor Bradley Olwin, the loss of skeletal muscle mass and function as we age can lead to sarcopenia, a debilitating muscle-wasting condition that generally hits the elderly hardest. The new study indicates that altering two particular cell-signaling pathways independently in aged mice enhances muscle stem cell renewal and improves muscle regeneration.
One cell-signaling pathway the team identified, known as p38 MAPK, appears to be a major player in making or breaking the skeletal muscle stem cell, or satellite cell, renewal process in adult mice, said Olwin of the molecular, cellular and developmental biology department. Hyperactivation of the p38 MAPK cell-signaling pathway inhibits the renewal of muscle stem cells in aged mice, perhaps because of cellular stress and inflammatory responses acquired during the aging process.
The researchers knew that obliterating the p38 MAPK pathway in the stem cells of adult mice would block the renewal of satellite cells, said Olwin. But when the team only partially shut down the activity in the cell-signaling pathway by using a specific chemical inhibitor, the adult satellite cells showed significant renewal, he said. “We showed that the level of signaling from this cellular pathway is very important to the renewal of the satellite cells in adult mice, which was a very big surprise,” said Olwin.
A paper on the subject appeared online Feb. 16 in the journal Nature Medicine.
One reason the CU-Boulder study is important is that the results could lead to the use of low-dose inhibitors, perhaps anti-inflammatory compounds, to calm the activity in the p38 MAPK cell-signaling pathway in human muscle stem cells, said Olwin.
The CU-Boulder research team also identified a second cell-signaling pathway affecting skeletal muscle renewal – a receptor known as the fibroblast growth factor receptor-1, or FGFR-1. The researchers showed when the FGFR-1 receptor protein was turned on in specially bred lab mice, the renewal of satellite cells increased significantly. “We still don’t understand how that particular mechanism works,” he said.
Another major finding of the study was that while satellite cells transplanted from young mice to other young mice showed significant renewal for up to two years, those transplanted from old mice to young mice failed. “We found definitively that satellite cells from an aged mouse are not able to maintain the ability to replenish themselves,” Olwin said. “This is likely one of the contributors to loss of muscle mass during the aging process of humans.”
Co-authors included first author and CU-Boulder postdoctoral researcher Jennifer Bernet, former CU-Boulder graduate student John K. Hall, CU-Boulder undergraduate Thomas Carter, and CU-Boulder postdoctoral researchers Jason Doles and Kathleen Kelly-Tanaka. The National Institutes of Health and the Ellison Medical Foundation funded the study.
Olwin said skeletal muscle function and mass decline with age in humans beginning at roughly age 40. While there are a variety of muscle-wasting diseases — ranging from muscular dystrophy to Lou Gehrig’s disease — the condition known as sarcopenia can lead to severe muscle loss, frailty and eventual death and is leading to skyrocketing health care costs for the elderly. “If you live long enough, you’ll get it,” he said.
Olwin and his team worked closely on the research with a team from Stanford University led by Professor Helen Blau, which published a companion paper in the same issue of Nature Medicine. “We shared data with the Stanford team during the entire process and we all were very pleased with the study outcomes,” said Olwin. “This is how science should work.”

CU study: We’re not so different than the Ancients
Feb 12th
rules of development, says CU-Boulder researcher
Recently derived equations that describe development patterns in modern urban areas appear to work equally well to describe ancient cities settled thousands of years ago, according to a new study led by a researcher at the University of Colorado Boulder.
“This study suggests that there is a level at which every human society is actually very similar,” said Scott Ortman, assistant professor of anthropology at CU-Boulder and lead author of the study published in the journal PLOS ONE. “This awareness helps break down the barriers between the past and present and allows us to view contemporary cities as lying on a continuum of all human settlements in time and place.”
Over the last several years, Ortman’s colleagues at the Santa Fe Institute (SFI), including Professor Luis Bettencourt, a co-author of the study, have developed mathematical models that describe how modern cities change as their populations grow. For example, scientists know that as a population increases, its settlement area becomes denser, while infrastructure needs per capita decrease and economic production per capita rises.
Ortman noticed that the variables used in these equations, such as cost of moving around, the size of the settled area, the population, and the benefits of people interacting, did not depend on any particular modern technology.
“I realized that if these models are adequate for explaining what’s going on in contemporary cities, they should apply to any settlements in any society,” he said. “So if these models are on the right track, they should apply to ancient societies too.”
To test his idea, Ortman used data that had been collected in the 1960s about 1,500 settlements in central Mexico that spanned from 1,150 years B.C. through the Aztec period, which ended about 500 years ago. The data included the number of dwellings the archaeologists were able to identify, the total settled area and the density of pottery fragments scattered on the surface. Taken together, these artifacts give an indication of the total population numbers and settlement density of the ancient sites.
“We started analyzing the data in the ways we were thinking about with modern cities, and it showed that the models worked,” Ortman said.
The discovery that ancient and modern settlements may develop in similar and predictable ways has implications both for archaeologists and people studying today’s urban areas. For example, it’s common for archaeologists to assume that population density is constant, no matter how large the settlement area, when estimating the population of ancient cities. The new equations could offer a way for archaeologists to get a more accurate head count, by incorporating the idea that population density tends to grow as total area increases.
In the future, the equations may also guide archaeologists in getting an idea of what they’re likely to find within a given settlement based on its size, such as the miles of roads and pathways. The equations could also guide expectations about the number of different activities that took place in a settlement and the division of labor.
“There should be a relationship between the population of settlements and the productivity of labor,” Ortman said. “So, for example, we would expect larger social networks to be able to produce more public monuments per capita than smaller settlements.”
The findings of the new study may also be useful to studies of modern societies. Because ancient settlements were typically less complex than today’s cities, they offer a simple “model system” for testing the equations devised to explain modern cities.
“The archaeological record actually provides surprisingly clear tests of these models, and in some cases it’s actually much harder to collect comparable data from contemporary cities,” Ortman said.
Other co-authors of the study include Andrew Cabaniss of Santa Fe Institute and the University of North Carolina Chapel Hill and Jennie Sturm of the University of New Mexico.
The study is available at http://dx.plos.org/10.1371/journal.pone.0087902.
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CU students will do your taxes for free
Jan 29th
tax preparation assistance
Students from the University of Colorado Boulder’s Leeds School of Business will offer free tax preparation services to individuals under the Internal Revenue Service-sponsored Volunteer Income Tax Assistance program.
Members of the public who make $52,000 or less are eligible for the service, now in its fifth year at the Leeds School.
The assistance will be available only on a walk-in basis Feb. 1 through April 5 on Wednesdays from 5 to 7:30 p.m. and Saturdays from 9 a.m. to 2 p.m. in the Koelbel Business Building, room 375. The building is located at 995 Regent Drive on the CU-Boulder campus, across from the Coors Events Center. Free parking is available after 5 p.m. and during the weekends at lot 436/494, located on Regent Drive north of the Coors Events Center and east of the Koelbel Business Building.
“Not only do student volunteers perform a much needed community service, but their work also is well received by potential employers,” said Susan Morley, senior instructor of accounting at the Leeds School.
Participating Leeds students have passed an IRS certification exam. Community volunteers who are experienced in tax law will review all student-prepared tax returns to ensure accuracy and completeness.
Last year, Leeds School students prepared approximately 380 tax returns and obtained more than $518,000 in refunds for taxpayers. The students also placed an extra $152,000 into the local economy through Earned Income Tax Credits for families.
Taxpayers who are eligible for the assistance should bring the following:
— Social Security cards or Individual Taxpayer Identification Notices/Cards for the taxpayer, the taxpayer’s spouse and dependents.
— Photo identification for the taxpayer and the taxpayer’s spouse if married and filing jointly. Both spouses must be present.
— All W-2 and 1099 forms and other income-related documents.
— Proof of mortgage interest, property taxes, daycare expenses (including provider’s tax ID number), college education expenses (e.g., 1098-T form) and all other applicable deductible expenses.
— A copy of last year’s federal tax return.
— Proof of account for direct deposit of refund (e.g., voided check).
— Proof of foreign status if applying for ITIN.
For more information about the accounting division at CU-Boulder’s Leeds School of Business visit http://leeds.colorado.edu/accounting#overview. For more information about the Leeds School visit http://leeds.colorado.edu/.
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