Posts tagged Arizona State
CU: study links autism symptons to gut germs
Dec 19th
gut microbes called ‘groundbreaking’
in CU-Boulder-authored journal article
A new study showing that feeding mice a beneficial type of bacteria can ameliorate autism-like symptoms is “groundbreaking,” according to University of Colorado Boulder Professor Rob Knight, who co-authored a commentary piece about the research appearing in the current issue of the journal Cell.
The autism study, published today in the same issue of Cell, strengthens the recent scientific understanding that the microbes that live in your gut may affect what goes on in your brain. It is also the first to show that a specific probiotic may be capable of reversing autism-like behaviors in mice.
“The broader potential of this research is obviously an analogous probiotic that could treat subsets of individuals with autism spectrum disorder,” wrote the commentary authors, who also included CU-Boulder Research Associate Dorota Porazinska and doctoral student Sophie Weiss.
The study underscores the importance of the work being undertaken by the newly formed Autism Microbiome Consortium, which includes Knight as well as commentary co-authors Jack Gilbert of the University of Chicago and Rosa Krajmalnik-Brown of Arizona State University. The interdisciplinary consortium—which taps experts in a range of disciplines from psychology to epidemiology—is investigating the autism-gut microbiome link.
For the new Cell study, led by Elaine Hsiao of the California Institute of Technology, the researchers used a technique called maternal immune activation in pregnant mice to induce autism-like behavior and neurology in their offspring. The researchers found that the gut microbial community of the offspring differed markedly compared with a control group of mice. When the mice with autism-like symptoms were fed Bacteriodes fragilis, a microbe known to bolster the immune system, the aberrant behaviors were reduced.
Scientific evidence is mounting that the trillions of microbes that call the human body home can influence our gut-linked health, affecting our risk of obesity, diabetes and colon cancer, for example. But more recently, researchers are discovering that gut microbes also may affect neurology—possibly impacting a person’s cognition, emotions and mental health, said Knight, also a Howard Hughes Medical Institute Early Career Scientist and an investigator at CU-Boulder’s BioFrontiers Institute.
The Autism Microbiome Consortium hopes to broaden this understanding by further studying the microbial community of autistic people, who tend to suffer from more gastrointestinal problems than the general public.
People with autism spectrum disorder who would like to have their gut microbes sequenced can do so now through the American Gut Project, a crowdfunded research effort led by Knight.
The consortium also includes Catherine Lozupone and Kimberly Johnson of CU-Boulder, James Adams of Arizona State University, Mady Hornig of Columbia University, Sarkis Mazmanian of the California Institute of Technology, John Alverdy of the University of Chicago and Janet Jansson of Lawrence Berkeley Lab.
For more information on the American Gut Project visit http://americangut.org.
-CU-
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Boyle lands TOP high school prospects
Nov 13th
by B.G. Brooks CUBuffs.com contributing editor
BOULDER – Not long after Tad Boyle was named Colorado men’s basketball coach in April 2010, he began a courtship of a slight but highly skilled Denver point guard named Dominique Collier.
Boyle had to get in line.
On the national recruiting scene, the most elite high school hoops circles began and ended with Collier. Scholarship offers arrived at the Collier home from Arizona, UCLA, Gonzaga, Oregon, Kansas State, Iowa and other schools highlighted on basketball’s national map.
But as the recruiting process went on, the clearer Collier’s decision became to him, the Buffs and several of the schools in pursuit. “The longer it went,” said Boyle, “it became pretty clear that he was ours to lose.”
The Buffs didn’t. And after narrowing the field in early May, Collier verbally committed to Boyle and the Buffs.
On Wednesday, he completed the promise, signing CU’s binding national letter of intent on the first day that high school prospects are allowed to do so. Also signing and returning CU’s national letter of intent was power forward Tory Miller, of New Hampton (N.H.) Prep.
Collier told BuffStampede.com that he “just like the way that (Boyle) has changed the program around. I like the way he coaches, the team and the relationships I have with the staff. It’s great to be born and raised in Colorado, go to high school in Colorado and then college in Colorado. I’m a Colorado kid. To go there and have all the support you could have, to follow in Chauncey Billup’s footsteps (means a lot).”
For Boyle, landing Collier represents another in-state recruiting milestone. Boyle and his staff managed to keep the in-state Class of 2012’s highest profile members – Josh Scott of Lewis-Palmer and Wesley Gordon of Sierra – at home.
“And outside of Josh and Wes,” said Boyle, “Dominique was the marquee recruit we had to keep home. We did – and we’re thankful and happy for it. He won’t be the last, but it’s critical for the program that we continue to have the success that we’ve had with those three.
“I said three-and-a-half years ago that if players of (Collier’s) caliber can help us win the Pac-12, then it’s imperative for us to get them. That’s what kind of player he is. I appreciate that he wanted to stay home. I’m very excited about it.”
Collier, said CU assistant Rodney Billups, was targeted early by CU, a move that obviously paid off: “Coach Boyle always said, ‘He’s our guy,’ and he got our best shot.”
Collier already lists several current CU players as friends, among them Scott and Gordon. They played together two seasons ago in an all-star game when Scott and Gordon were finishing at their respective high schools. The 6-10 Scott played last season as a true freshman, while the 6-9 Gordon redshirted. The high school rivals finally are sharing court time on this year’s Buffs team, which plays Wyoming Wednesday (7 p.m.) at the Coors Events Center.
Boyle said the Collier family “became part of our family” during the recruitment process and called working with veteran Denver East coach Rudy Carey a “tremendous experience.”
Collier has often stated a desire to emulate CU legend Chauncey Billups, who went on to make a lasting mark in the NBA. Rodney, Billups’ younger brother, was key in Collier’s recruitment – “Maybe more so than I was,” Boyle said. “Rodney obviously has ties in the Denver basketball community. He really was our lead recruiter (on Collier). Dominique’s family (parents Lori and Darryl) love Rodney; he made a good connection with them.”
“I’ve had a relationship with ‘Dom’ for a long time now,” Rodney Billups said. “He started out with Billups Elite when he was a freshman, really going into his eighth grade year. I had a chance before I was even at Colorado to build a relationship with him and his family. Just talking to him and recruiting him was kind of easy for me.”
Collier, an only child, is “a great kid, shy at times, but his personality really comes out on the court,” Rodney Billups said. “There’s a good balance there for him to have a really good character. Staying home was important to him and his family, especially Lori – that’s her baby. She wants him close.”
Boyle said landing Collier and Miller fills two needs for the Buffs – a savvy ball-handler in Collier who is a “terrific talent and great defender” and a big-bodied “enforcer type” in Miller.
A capsule look at CU’s two 2014 signees:
DOMINIQUE COLLIER
Position: Point guard
Height: 6-1
Weight: 166
High school: Denver East
Vital stats/storylines: Averaged 20.1 points, 3.6 assists, 5.0 rebounds, 3.5 steals and 1.3 blocks per game as a junior; East went 25-3, lost to Eaglecrest in the 5A state championship game at the Coors Events Center . . . . Four-star prospect, currently ranked No. 94 nationally . . . Collier was named Colorado Mr. Basketball and Gatorade Player of the Year after junior season . . . . Top western schools – including Pac-12 members Arizona, Arizona State and UCLA – took an intense in Collier during his sophomore and early in his junior seasons. But as the recruiting process lengthened it became apparent that he had targeted CU . . . Iowa and Kansas State also joined the pursuit . . . . Collier verbally committed to the Buffs on May 7.
CU scouting report: A pass-first, very unselfish type of point guard who already has international basketball experience (USA Basketball, three-on-three competition in Indonesia with FIBA’s USA team) gained through summer travels . . . . Can get wherever he wants to on the court with his tremendous first step and ball-handling skills . . . . A very good on-ball defender with great anticipation.
Boyle’s take: “He’s got a good basketball body, but he’s a little slight right now and knows he going to spend some time in the weight room. I love that he can get wherever he wants to go on the court. Plus, he’s got lots of experience – more than the typical incoming freshman. I expect him to have an impact right away. In fact, I’m counting on it.”
TORY MILLER
Position: Power forward
Height: 6-8
Weight: 255
High school: New Hampton (N.H.) Prep
Vital stats/storylines: Averaged 12.3 points, 6.0 rebounds and shot 58.7 percent from the field last year in his junior season at New Hampton . . . . A three-star prospect whose rating could rise after his senior season . . . . Miller is from the Kansas City area and played on the same AAU team (Kansas City Run GMC) as fellow CU signee Collier . . . . Took official visits to Arizona State, Marquette and Iowa, but committed to CU over Marquette on Oct. 19 . . . . Eric Bossi, Rivals.com’s national basketball recruiting analyst, said Miller “can be a rugged rebounder and explosive finisher around the rim capable of playing through contact. (He) can also step out and make 12-to-15 foot jumpers with pretty good regularity . . . and he’s physically ready to play in the Pac-12.”
CU scouting report: Big, wide-bodied player who is physically ready to compete at the next level . . . . Roster is well-stocked with runners, jumpers and finesse-type players – and Miller also can play with finesse, but he’s best as an enforcer type . . . . Good hands, long arms make him a capable shot blocker; plays bigger than 6-8 . . . . What makes him special is his big body, his ability to use to his advantage on defense and his ability to lower his center of gravity, making him difficult to move.
Boyle’s take: “Tory gives us a wide presence that we haven’t had since I’ve been here. He’s a skilled player and very competitive. With his body type and strength, he can finish down low with contact. He doesn’t look like he would be a good jumper, but he is. Plus, he’s 19 years old now and will bring an age and maturity level to us that’s a little further along than you’d find in a typical freshman. He’s got all the physical tools necessary to be a very good Pac-12 player and he understands what it means to be successful.”
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Buffs wallop Charleston Southern 43-10
Oct 19th
Game Story by B.G. Brooks CUBuffs.com contributing editor
BOULDER – Stepping away from their Pac-12 Conference schedule on a perfect mid-October Saturday, the Colorado Buffaloes eventually stepped out of Folsom Field with a 43-10 romp past overmatched Charleston Southern.
The Buffs’ Big Stepper was tailback Michael Adkins II.
Adkins, a true freshman from San Diego, accounted for a freshman school record four touchdowns on runs of 23, 5, 33 yards and 34 yards. Entering Saturday’s game, the Buffs had scored one rushing TD in their previous five games.
“We always say we want to be about 50-50 (run-pass), it depends on how the game goes,” said Adkins, who finished with 137 yards on 13 carries. “But running today definitely was a factor.”
And how. Tailback/fullback Christian Powell also scored on a 2-yard run as the Buffs enjoyed their most productive running afternoon of the season (218 yards). Adkins’ four TDs eclipsed the school freshman record set by Herschel Troutman in 1994 and equaled by Powell last season.
The Buffs’ top rushing effort this season had been 154 yards in a 44-17 loss at Oregon State. In the two games before Saturday, they had totaled 94 yards against Oregon and 99 against Arizona State. Adkins’ carries had steadily risen in the three previous games, with his 98 yards on 14 attempts at OSU the previous high mark for a CU back this season.
“My carries have been increasing every week so I just took advantage of the carries I got,” Adkins said. “Our line blocked well and I just kept grinding and kept finding the holes . . . it gave me a lot of confidence. I didn’t score in my first two games, so scoring today gives me a lot of confidence moving forward.”
The Buffs broke a three-game losing streak, evened their record at 3-3 and won their first game under first-time starting quarterback Sefo Liufau. CU returns to Pac-12 competition and remain at home next weekend, hosting Arizona (6 p.m., Pac-12 Network) in a game that suddenly looms as perhaps the schedule’s most pivotal.
With Saturday’s win, CU’s goal now becomes to win its first Pac-12 game under first-year coach Mike MacIntyre next week and exit October 4-3 overall. That leaves five conference games in the season’s final month for the Buffs to get two wins and reach six for bowl qualification – something that hasn’t happened since the 2006 season.
“If we get the one next week,” said MacIntyre, “it means November matters in Colorado.”
A true freshman from Tacoma, Wash., Liufau made his college debut last weekend at Arizona State, replacing junior Connor Wood in the first quarter of CU’s 54-13 loss. Liufau finished 18-of-26 for 169 yards and a touchdown, with two interceptions, in that game.
In his first start Saturday, he was 14-of-20 for 198 yards. Liufau’s TD pass covered 60 yards, most of them courtesy of fleet junior Paul Richardson in the second quarter. Richardson finished with eight receptions for 122 yards.
“It feels good,” Liufau said of his home debut and first start. “It was fun being out there with the guys and just playing and having fun.” He called he confidence gained from the win “a tribute to the team – the O-line blocking, the receivers running the routes. Paul had a great play there . . . I definitely got confidence as I kept going.”
The game against previously unbeaten CSU, the FCS’ No. 24-ranked team, was arranged last month to replace Fresno State on the CU schedule. The Fresno State contest was postponed due to the mid-September floods that ravaged Boulder and Boulder County.
“I’m thankful that Charleston Southern wanted to play us,” MacIntyre said. “Or we couldn’t have played today.”
CSU, which entered the afternoon 7-0, was without its first two quarterbacks and started freshman Kyle Copeland, who was playing in only his third game and had thrown two incompletions in his only two attempts. Copeland’s final passing stats: 7-of-14 for 48 yards, one TD, one interception.
CU outgained CSU 416-196 in total offense, with the Buffs adjusting to the Buccaneers’ option attack and holding them to zero points and 46 total yards in the second half.
“(CU) is just a better team than us,” said CSU coach Jamey Chadwell. “We had seven wins before today and I don’t think that’s going to change. The only difference is that won’t play quite as good of a team. They made some good adjustments during the second half, and as for us, we’re going to keep doing what we do.”
The Buffs got out of the first half with a 22-10 lead largely made possible by a timely fumble recovery by Nate Bonsu and Richardson’s runaway speed.
Bonsu got the loose ball following defensive end Chidera Uzo-Diribe’s strip of CSU quarterback Kyle Copeland at the Buccaneers’ 12-yard line in the second quarter. Two plays later, Adkins took a handoff headed off left tackle, weaved to his right and scored from 5 yards out.
Will Oliver’s PAT staked CU to a 15-3 lead that ballooned to 22-3 after a three-and-out CSU series and a 60-yard pitch-and-catch executed by Liufau and Richardson.
Credit Liufau with keeping the play afloat; he fielded a bouncing center snap, collected himself and spotted Richardson crossing right to left in front of the formation. “P-Rich” took the short pass, reversed his field and outran two Buccaneers in pursuit to the right pylon.
Oliver again kicked the extra point and CU seemed comfortably ahead 22-3. The Buffs had opened the game with a 65-yard, six-play scoring drive, getting 52 yards on the ground – the last 23 by Adkins. They went ahead 8-0 when holder Darragh O’Neill ran for the two-point conference.
But after CU had surged in front 22-3, CSU collected itself for its second 9-plus minute drive of the half – the first ended with a field goal when an apparent TD pass on a well-designed pitch was reviewed and overruled – and scored on a 7-yard Copeland to Colton Korn with six left before intermission.
The disallowed TD proved pivotal. The play initially was reviewed and not overturned, but MacIntyre called a time out to allow another look and said he was told by an official that the ball being bobbled by tight end Nathan Prater was missed on the first look.
Chadwell said he was upset because “they took a time out, they reviewed the play (and) it was fine. Then the other review took an hour. They (officials) didn’t go by their protocol . . . I just felt like it was huge deal momentum-wise, because that could have meant a touchdown for us.”
CU, which was leading 8-0 at the time, finished the half with 164 yards in total offense, while CSU had 150. Liufau attempted only six first-half passes, completing four for 74 yards – Richardson’s long TD was for 60 – and being sacked once. Copeland, playing in only his second game and 0-2 in passing, was five-for-eight for 27 yards and a TD. The Buccaneers controlled the ball for 21:51 to 8:09 in the opening half.
The Buffs scored on their first possession of the second half, opening a 29-10 lead after a 13-play, 64-yard march capped by Christian Powell’s 2-yard run. Exactly 3 minutes later – at 4:11 – Liufau and his offense failed to capitalize on a Jered Bell interception near midfield, and the quarter ended with CU clutching its 19-point lead.
With 11:22 to play, Adkins’ 33-yard jaunt and Oliver’s extra point sent the Buffs comfortably ahead 36-10. Just over 5 minutes later, Adkins broke loose again and broke three tackles en route to his record-setting fourth rushing TD.
Wood replaced Liufau and Tony Jones replaced Adkins with just over 3 minutes remaining, with CU taking possession near its 15-yard line and ending the game near midfield.
Contact: BG.Brooks@Colorado.EDU
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