Posts tagged Chicago
CU: study links autism symptons to gut germs
Dec 19th
gut microbes called ‘groundbreaking’
in CU-Boulder-authored journal article
A new study showing that feeding mice a beneficial type of bacteria can ameliorate autism-like symptoms is “groundbreaking,” according to University of Colorado Boulder Professor Rob Knight, who co-authored a commentary piece about the research appearing in the current issue of the journal Cell.
The autism study, published today in the same issue of Cell, strengthens the recent scientific understanding that the microbes that live in your gut may affect what goes on in your brain. It is also the first to show that a specific probiotic may be capable of reversing autism-like behaviors in mice.
“The broader potential of this research is obviously an analogous probiotic that could treat subsets of individuals with autism spectrum disorder,” wrote the commentary authors, who also included CU-Boulder Research Associate Dorota Porazinska and doctoral student Sophie Weiss.
The study underscores the importance of the work being undertaken by the newly formed Autism Microbiome Consortium, which includes Knight as well as commentary co-authors Jack Gilbert of the University of Chicago and Rosa Krajmalnik-Brown of Arizona State University. The interdisciplinary consortium—which taps experts in a range of disciplines from psychology to epidemiology—is investigating the autism-gut microbiome link.
For the new Cell study, led by Elaine Hsiao of the California Institute of Technology, the researchers used a technique called maternal immune activation in pregnant mice to induce autism-like behavior and neurology in their offspring. The researchers found that the gut microbial community of the offspring differed markedly compared with a control group of mice. When the mice with autism-like symptoms were fed Bacteriodes fragilis, a microbe known to bolster the immune system, the aberrant behaviors were reduced.
Scientific evidence is mounting that the trillions of microbes that call the human body home can influence our gut-linked health, affecting our risk of obesity, diabetes and colon cancer, for example. But more recently, researchers are discovering that gut microbes also may affect neurology—possibly impacting a person’s cognition, emotions and mental health, said Knight, also a Howard Hughes Medical Institute Early Career Scientist and an investigator at CU-Boulder’s BioFrontiers Institute.
The Autism Microbiome Consortium hopes to broaden this understanding by further studying the microbial community of autistic people, who tend to suffer from more gastrointestinal problems than the general public.
People with autism spectrum disorder who would like to have their gut microbes sequenced can do so now through the American Gut Project, a crowdfunded research effort led by Knight.
The consortium also includes Catherine Lozupone and Kimberly Johnson of CU-Boulder, James Adams of Arizona State University, Mady Hornig of Columbia University, Sarkis Mazmanian of the California Institute of Technology, John Alverdy of the University of Chicago and Janet Jansson of Lawrence Berkeley Lab.
For more information on the American Gut Project visit http://americangut.org.
-CU-
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Professor grabs 8th MacArthur award for CU faculty
Sep 25th
Rey also is an assistant research professor in the CU-Boulder Department of Physics. She teaches undergraduate and graduate classes.
Rey is the eighth CU-Boulder faculty member to win the prestigious award from the John D. and Catherine T. MacArthur Foundation of Chicago as well as the fourth physics faculty member and third JILA fellow. Rey, 36, was one of 24 recipients of the 2013 “no-strings attached” funding. She will receive $625,000 paid out over five years.
“It is a great honor for me to be a MacArthur fellow and to receive such great recognition of my work,” Rey said. “I want to thank JILA, NIST, CU-Boulder and the outstanding group of colleagues, collaborators and students who have allowed and helped me to accomplish the research I have done.”
The MacArthur Foundation selection committee cited Rey as an “atomic physicist advancing our ability to simulate, manipulate, and control novel states of matter through fundamental conceptual research on ultra-cold atoms.”
“We congratulate Professor Rey on this exciting award, and, we also congratulate our faculty, whose ranks now include five Nobel laureates and eight MacArthur Fellowship winners,” said CU-Boulder Chancellor Philip P. DiStefano. “I believe Professor Rey’s work is emblematic of the research, innovation, and discovery at CU-Boulder, a body of work and a collection of great minds that is unmatched anywhere in the Rocky Mountain region and few places around the nation.”
Tom O’Brian, chief of the NIST Quantum Physics Division and Rey’s supervisor, said, “Ana Maria has rapidly established herself as one of the world’s top young theoretical physicists. She has a special ability to make very practical applications of theory to key experiments. Ana Maria has been crucial to the success of such world-leading NIST/JILA programs as ultracold molecules, dramatic improvements in optical lattice clocks, and use of cold atom systems and trapped ion systems for quantum simulations.”
At JILA, Rey works with ultracold atoms and molecules that are trapped in an “optical lattice,” a series of shallow wells constructed of laser light. Atoms that are loaded into an optical lattice behave similarly to electrons in a solid crystal structure. But while it’s difficult to change the properties of a solid crystal, the properties of an optical lattice—which essentially acts as a “light crystal”—are highly controllable, allowing Rey to explore a whole range of phenomena that would be nearly impossible to study in a solid crystal system.
Ultimately, Rey hopes her research will lead to the ability to engineer materials with unique characteristics such as superfluids—liquids that appear to move without regard for gravity or surface tension—and quantum magnets—individual atoms that act like tiny bar magnets.
Rey began studying physics at the Universidad de los Andes in Bogota, Colombia, where she received a Bachelor of Science degree in 1999. She came to the United States to continue her studies, earning a doctorate in physics from the University of Maryland, College Park in 2004.
Before coming to JILA in 2008, Rey was a postdoctoral fellow at the Harvard-Smithsonian Center for Astrophysics in Cambridge, Mass., and a postdoctoral researcher at NIST in Gaithersburg, Md.
Previous CU-Boulder faculty members who have won a MacArthur Fellowship include David Hawkins of philosophy in 1981, Charles Archambeau of physics in 1988, Patricia Limerick of history in 1995, Margaret Murnane of physics and JILA in 2000, Norman Pace of molecular, cellular and developmental biology in 2001, Daniel Jurafsky of linguistics and the Institute of Cognitive Science in 2002 and Deborah Jin of JILA, NIST and physics in 2003.
“Everyone at JILA is extremely proud of Ana Maria Rey’s accomplishments and wholeheartedly congratulate her for this prestigious MacArthur Fellowship,” said JILA Chair Murray Holland. “She has an incredibly quick mind for physics and is one of the truly creative and ingenious scientists of her time, while also being a wonderful teacher and mentor to both undergraduate and graduate students. This is a great honor for Ana Maria, and a tremendous recognition of the important research programs in JILA and NIST.”
Rey is a highly effective mentor for an unusually large group of graduate students and postdoctoral fellows given the early stage of her career, O’Brian said. One of her recent graduate students, Michael Foss-Feig, won the prestigious 2013 Best Thesis Award of the American Physical Society’s Division of Atomic, Molecular and Optical Physics. Rey herself won the same award in 2005 as a graduate student at the University of Maryland.
On Sept. 24, in another honor, the American Physical Society named Rey the winner of the 2014 Maria Goeppert Mayer Award, which recognizes outstanding achievements by a woman physicist in her early career:
Additional information on Rey is available on the Web at http://www.macfound.org/fellows/901 and http://jila-amo.colorado.edu/science/profiles/ana-maria-rey.
-CU-
Lyndi McCartney, wife of former CU coach Bill McCartney, dies of emphysema
Mar 21st
WESTMINSTER – Lyndi McCartney, the wife of former University of Colorado football coach Bill McCartney, passed away Thursday afternoon after a lengthy, hard-fought battle with emphysema. She was 70.
“We have four children and 10 grandchildren and we all loved her very much,” Bill McCartney said of his wife for a half century; the two celebrated their 50th wedding anniversary last Dec. 29.
Lyndi spent her last days in Hospice care and was surrounded by family when she finally succumbed after decade-plus long battle against the disease. Grandsons, the sons of daughter Kristy, T.C., a CU graduate assistant coach, and Derek, a freshman on the football team, were among those present when she passed.
The eldest McCartney son, Mike, announced his mother’s passing on his Facebook page with simply, “RIP Mom. I am who I am because of you. Love you.” He works as a player’s representative with Priority Sports out of Chicago.
The youngest son, Marc, posted this on Facebook: “Today I mourn, but my mom suffers no more. She is forever in heaven now and that gives me a great peace that surpasses all understanding. Thank you to all of the people who loved my mom and have been praying for her. Your thoughts and prayers have been a great encouragement and comfort to me and my family.” Marc is the vice president for special events with RightNow, a non-profit ministry in Rockwall, Texas
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The couples’ other son, Tom, is the football coach at Fairview High School in Boulder.
Services are pending.
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