Posts tagged discovery
Happy Trails Riding Center – Summer Camps and Activities
May 21st
We talk with Chris about all the great things they offer at the Happy Trails Riding Center facility. Their main focus is children and helping provide a natural atmosphere and educational environment to not only ride horses but and build a foundation for leadership with other peers. The riding center offers a full boarding center and 3 large riding and training areas, as well as many summer camps that involve horse training, care, riding, science discovery, fun with animals, camping, horse shows and lots of other great outdoor activities for the kids.
CU Boulder researchers uncover new target for cancer research
Oct 25th
Researchers in the two scientists’ laboratories collaborated to find a patch of amino acids that, if blocked by a drug docked onto the chromosome end at this location, may prevent cancerous cells from reproducing. The amino acids at this site are called the “TEL patch” and once modified, the end of the chromosome is unable to recruit the telomerase enzyme, which is necessary for growth of many cancerous cells.
“This is an exciting scientific discovery that gives us a new way of looking at the problem of cancer,” Cech said. “What is amazing is that changing a single amino acid in the TEL patch stops the growth of telomeres. We are a long way from a drug solution for cancer, but this discovery gives us a different, and hopefully more effective, target.”
Cech is the director of the BioFrontiers Institute, a Howard Hughes Medical Investigator and winner of the 1989 Nobel Prize in chemistry.
Co-authors on the study include postdoctoral fellows Jayakrishnan Nandakumar and Ina Weidenfeld; University of Colorado undergraduate student Caitlin Bell; and Howard Hughes Medical Institute Senior Scientist Arthur Zaug.
Telomeres have been studied since the 1970s for their role in cancer. They are constructed of repetitive nucleotide sequences that sit at the ends of our chromosomes like the ribbon tails on a bow. This extra material protects the ends of the chromosomes from deteriorating, or fusing with neighboring chromosome ends. Telomeres are consumed during cell division and, over time, will become shorter and provide less cover for the chromosomes they are protecting. An enzyme called telomerase replenishes telomeres throughout their lifecycles.
Telomerase is the enzyme that keeps cells young. From stem cells to germ cells, telomerase helps cells continue to live and multiply. Too little telomerase produces diseases of bone marrow, lungs and skin. Too much telomerase results in cells that over proliferate and may become “immortal.” As these immortal cells continue to divide and replenish, they build cancerous tumors. Scientists estimate that telomerase activation is a contributor in up to 90 percent of human cancers.
To date, development of cancer therapies has focused on limiting the enzymatic action of telomerase to slow the growth of cancerous cells. With their latest discovery, Cech and Leinwand envision a cancer drug that would lock into the TEL patch at chromosome ends to keep telomerase from binding there. This approach of inhibiting the docking of telomerase may be the elegant solution to the complex problem of cancerous cells. Cech, a biochemist, and Leinwand, a biologist, joined forces to work on their latest solution.
“This work was really made possible by the fact that our labs are so close,” Leinwand said. “My lab was able to provide the cell biology and understanding of genetics, and Tom’s lab allowed us to explore the biochemistry. We have a unique situation at BioFrontiers where labs and people comingle to make discoveries just like this.”
Leinwand is the chief scientific officer of the BioFrontiers Institute and a professor of molecular, cellular and developmental biology.
Researchers at the University of Colorado have a significant history in developing marketable biotechnologies. Cech founded Ribozyme Pharmaceuticals Inc. Leinwand co-founded Myogen with CU professor Michael Bristow, Hiberna and recently launched MyoKardia (http://www.myokardia.com/about.php).
The BioFrontiers Institute is an interdisciplinary institute housed at the Jennie Smoly Caruthers Biotechnology Building at CU-Boulder. The institute is dedicated to training the next generation of interdisciplinary scientists through its IQ Biology Interdisciplinary Quantitative Biology Ph.D. program. For more information about BioFrontiers visithttp://biofrontiers.colorado.edu
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Fourmile canyon blaze yields new insight into climate change, CU scientists say
Aug 27th
heat-trapping effects of wildfire smoke particles
When the Fourmile Canyon Fire erupted west of Boulder in 2010, smoke from the wildfire poured into parts of the city including a site housing scientists from the University of Colorado Boulder’s Cooperative Institute for Research in Environmental Sciences and the National Oceanic and Atmospheric Administration.
Within 24 hours, a few researchers at the David Skaggs Research Center had opened up a particle sampling port on the roof of the building and started pulling in smoky air for analysis by two custom instruments inside. They became the first scientists to directly measure and quantify some unique heat-trapping effects of wildfire smoke particles.
“For the first time we were able to measure these warming effects minute-by-minute as the fire progressed,” said CIRES scientist Dan Lack, lead author of the study published today in the Proceedings of the National Academy of Sciences.
The researchers also were able to record a phenomenon called the “lensing effect,” in which oils from the fire coat the soot particles and create a lens that focuses more light onto the particles. This can change the “radiative balance” in an area, sometimes leading to greater warming of the air and cooling of the surface.
While scientists had previously predicted such an effect and demonstrated it in laboratory experiments, the Boulder researchers were one of the first to directly measure the effect during an actual wildfire. Lack and his colleagues found that lensing increased the warming effect of soot by 50 to 70 percent.
“When the fire erupted on Labor Day, so many researchers came in to work to turn on instruments and start sampling that we practically had traffic jams on the road into the lab,” Lack said. “I think we all realized that although this was an unfortunate event, it might be the best opportunity to collect some unique data. It turned out to be the best dataset, perfectly suited to the new instrument we had developed.”
The instrument called a spectrophotometer can capture exquisite detail about all particles in the air, including characteristics that might affect the smoke particles’ tendency to absorb sunlight and warm their surroundings. While researchers know that overall, wildfire smoke can cause this lensing effect, the details have been difficult to quantify, in part because of sparse observations of particles from real-world fires.
Once the researchers began studying the data they collected during the fire, it became obvious that the soot from the wildfire was different in several key ways from soot produced by other sources — diesel engines, for example.
“When vegetation burns, it is not as efficient as a diesel engine, and that means some of the burning vegetation ends up as oils,” Lack said. In the smoke plume, the oils coated the soot particles and that microscopic sheen acted like a magnifying glass, focusing more light onto the soot particles and magnifying the warming of the surrounding air.
The researchers also discovered that the oils coating the soot were brown, and that dark coloration allowed further absorption of light, and therefore further warming the atmosphere around the smoke plume.
The additional warming effects mean greater heating of the atmosphere enveloped in dark smoke from a wildfire, and understanding that heating effect is important for understanding climate change, Lack said. The extra heating also can affect cloud formation, air turbulence, winds and even rainfall.
The discovery was made possible by state-of-the-art instruments developed by CIRES, NOAA and other scientists, Lack said. The instruments can capture fine-scale details about particles sent airborne by the fire, including their composition, shape, size, color and ability to absorb and reflect sunlight of various wavelengths.
“With such well-directed measurements, we can look at the warming effects of soot, the magnifying coating and the brown oils and see a much clearer, yet still smoky picture of the effect of forest fires on climate,” Lack said.