Posts tagged John
Boulder Chamber – Boulder Business After Hours with Jane Lewis – February 19th 2014
Feb 26th
Jane Lewis – Boulder Chamber’s Event, Website and Possibilities Manager sits down with Jann Scott from Boulder Channel 1 and tells us about the Boulder Business After Hours event and other upcoming Boulder Chamber events.
Feb 19th, 2014 – Boulder Business After Hours – has become the one of the most popular ways to meet, learn from and get connected with local business leaders and influencers. at the Historic Boulderado Hotel.
Feb 25th, 2014 – Boulder Tech Job Fair at the Chamber – Come meet with some exciting companies that are hiring.
Feb 26th, 2014 – Boulder 2140 Five Year Anniversary – Young Boulder professionals meet at BMoCA for a celebration of 5 years!
Mar 5th, 2014 – Policy Round Table – Meeting for potential enhancements and improvements to the transportation system in Boulder.
Mar 6th, 2014 – Membership Orientation – Come learn what its all about to become a member of the Boulder Chamber.
Mar 10th, 2014 – Open Office Hours with John Tayer – Talk with the head of the Chamber and share your ideas or concerns with business in Boulder
Mar 12th, 2014 – BWLG Practical Steps for Social Media – Learn about strategies for Social Media as a business and how it can help strengthen your online marketing presence.
Mar 13th, 2014 – DIY Corporate Video Workshop – Learn how to make a video for your company using professional video techniques.
CU: Stem cells boost aging muscles
Feb 16th
to new methods of mitigating muscle loss
New findings on why skeletal muscle stem cells stop dividing and renewing muscle mass during aging points up a unique therapeutic opportunity for managing muscle-wasting conditions in humans, says a new University of Colorado Boulder study.
According to CU-Boulder Professor Bradley Olwin, the loss of skeletal muscle mass and function as we age can lead to sarcopenia, a debilitating muscle-wasting condition that generally hits the elderly hardest. The new study indicates that altering two particular cell-signaling pathways independently in aged mice enhances muscle stem cell renewal and improves muscle regeneration.
One cell-signaling pathway the team identified, known as p38 MAPK, appears to be a major player in making or breaking the skeletal muscle stem cell, or satellite cell, renewal process in adult mice, said Olwin of the molecular, cellular and developmental biology department. Hyperactivation of the p38 MAPK cell-signaling pathway inhibits the renewal of muscle stem cells in aged mice, perhaps because of cellular stress and inflammatory responses acquired during the aging process.
The researchers knew that obliterating the p38 MAPK pathway in the stem cells of adult mice would block the renewal of satellite cells, said Olwin. But when the team only partially shut down the activity in the cell-signaling pathway by using a specific chemical inhibitor, the adult satellite cells showed significant renewal, he said. “We showed that the level of signaling from this cellular pathway is very important to the renewal of the satellite cells in adult mice, which was a very big surprise,” said Olwin.
A paper on the subject appeared online Feb. 16 in the journal Nature Medicine.
One reason the CU-Boulder study is important is that the results could lead to the use of low-dose inhibitors, perhaps anti-inflammatory compounds, to calm the activity in the p38 MAPK cell-signaling pathway in human muscle stem cells, said Olwin.
The CU-Boulder research team also identified a second cell-signaling pathway affecting skeletal muscle renewal – a receptor known as the fibroblast growth factor receptor-1, or FGFR-1. The researchers showed when the FGFR-1 receptor protein was turned on in specially bred lab mice, the renewal of satellite cells increased significantly. “We still don’t understand how that particular mechanism works,” he said.
Another major finding of the study was that while satellite cells transplanted from young mice to other young mice showed significant renewal for up to two years, those transplanted from old mice to young mice failed. “We found definitively that satellite cells from an aged mouse are not able to maintain the ability to replenish themselves,” Olwin said. “This is likely one of the contributors to loss of muscle mass during the aging process of humans.”
Co-authors included first author and CU-Boulder postdoctoral researcher Jennifer Bernet, former CU-Boulder graduate student John K. Hall, CU-Boulder undergraduate Thomas Carter, and CU-Boulder postdoctoral researchers Jason Doles and Kathleen Kelly-Tanaka. The National Institutes of Health and the Ellison Medical Foundation funded the study.
Olwin said skeletal muscle function and mass decline with age in humans beginning at roughly age 40. While there are a variety of muscle-wasting diseases — ranging from muscular dystrophy to Lou Gehrig’s disease — the condition known as sarcopenia can lead to severe muscle loss, frailty and eventual death and is leading to skyrocketing health care costs for the elderly. “If you live long enough, you’ll get it,” he said.
Olwin and his team worked closely on the research with a team from Stanford University led by Professor Helen Blau, which published a companion paper in the same issue of Nature Medicine. “We shared data with the Stanford team during the entire process and we all were very pleased with the study outcomes,” said Olwin. “This is how science should work.”
The Seahawks are swell. We all agree.
Feb 7th
The Seahawks’ magical 2013 season had come to its official end with a parade through more than 700,000 cheering fans and a championship celebration before 50,000 going-bonkers 12th Man fans at CenturyLink Field and 27,000 more at Safeco Field across the street. It was a sendoff befitting a Super Bowl champion, which the Seahawks became with their 43-8 victory over the Denver Broncos on Sunday night.
Before he left the stadium Wednesday, coach Pete Carroll held one more Q&A session with the media – in the same room where he had addressed them after each of the Seahawks’ 10 home games during the regular season and postseason.
But this one was different, because this season was different. For starters, it ended later than all but one of the Seahawks’ previous 37 seasons – with the exception being 2005, when the Seahawks lost to the Pittsburgh Steelers in Super XL on Feb. 5, 2006.
So coach, are you behind already in the quest to not only defend, but extend, the Seahawks’ reign as Super Bowl champs?
“No,” Carroll said. “John (Schneider, the general manger) is all over it. So no, not at all.”
While the team was in New Jersey last week preparing for the Super Bowl, Schneider was meeting with his staff to prepare for the NFL Scouting Combine Feb. 19-25, the next big step for the May 8-10 NFL Draft; as well as the free agency period, which begins March 11.
As has been the case since Carroll and Schneider arrived in 2010, their first priority is retaining their own players who are scheduled to become free agents – a list that includes defensive lineman Michael Bennett, who led the team in sacks; and wide receiver Golden Tate, who led the team in receiving.
“We want this team together, we want to see if we can keep this team together,” Carroll said. “Every decision is difficult that we have to face. And guys that are at the end of their contracts, those are big issues for us. We love the guys; we love what they do and what they bring. And we’d like to keep it together as best we can.
“John will be faced with some really challenging discussions and things to get that done, but we’ll be very much in concert on it and what we want to get done and then we’ll go set about it one step at a time. And it’ll take us a good while, always with our eye on what’s going on with the draft and all that, and we’ll see if we put it together just right.”
PHOTO GALLERY: Players Celebrate 48
As for free agency, the Seahawks will be choosey, as they have been in the past, because they can afford to be after what Schneider and Carroll have done the past four offseasons.
“We have what we need,” Carroll said. “We just need to get back to work, when the time comes, with the right attitude and the right focus. That’s all I’m concerned about. We’ll have an opportunity to add some players to our team through the draft and all. We’ll take a good look at free agency.
“I don’t see anything that we need to add. We just need to get better.”
The players will be around Virginia Mason Athletic Center in the coming weeks and months, but the offseason program does not start until April 21.
“It seems like forever,” Carroll said. “I think we walk out of here totally arm in arm with the fact that we’re going to have a great offseason. That means that the guys have to be totally committed to having a great offseason, because they’re going to have a lot of distractions and a lot of people pulling them in different directions.”
Carroll addressed that during the final team meeting on Tuesday, when the players also cleaned out their lockers and took their exit physicals.
“Quite frankly, each guy’s got to set his plan in motion and not let the distractions get in the way of the hard work that it takes to put this thing back together again,” Carroll said.
“It’s an extraordinary opportunity, because it’s so difficult for teams to come back and play well after winning the Super Bowl. We take that challenge on now, nose to nose. We’re going to go after it and see what we can do about it.”
And Carroll doesn’t care for talk of a repeat – as no team has repeated as Super Bowl champion since the New England Patriots in 2003 and 2004, and they were the first to do it since the Broncos in 1997 and 1998. Or even the Super Bowl, for that matter. He’s all about improving each day, which allows you to improve each week, which allows you to improve each season.
“Let me say it even more specifically, it’s not about repeating to me,” he said. “That isn’t it. We’re trying to do something really good for a really long time. And we want to see how far we can go, and someday we can look back and see what we accomplished. In the middle of it, I don’t think it’s time to assess it.
PHOTO GALLERY: Fans Celebrate 48
“In this year, I never talked about the Super Bowl. I talked about trying to help these guys be the best they possibly can be.”
And in 2013, the Seahawks were the best in team in all of football.