Beth (Diane Keaton) saves a bedraggled lost dog from the side of the freeway on a wintry day in Denver. Struggling with her distracted, self-involved husband Joseph (Kevin Kline) and an empty nest at home, Beth forms a special bond with the rescued animal. When Joseph loses the dog after their daughter’s (Elisabeth Moss) wedding at their vacation home in the Rockies, Beth, distraught and angry with Joseph, enlists the help of the few remaining guests (Dianne Wiest, Richard Jenkins, Mark Duplass) and a mysterious woman (Ayelet Zurer) in a frantic search.