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CU team receives $9.2 million DOE grant to engineer E. coli into biofuels
Dec 4th
“This is a fantastic opportunity to take what we have worked on for the past decade to the next level,” said team leader Ryan Gill, a fellow of CU-Boulder’s Renewable and Sustainable Energy Institute, or RASEI. “In this project, we will develop technologies that are orders of magnitude beyond where we are currently.”
The team is working with a non-pathogenic strain of E. coli. Among the microbe’s more than 4,000 genes, the team is searching for a small set and how it can be manipulated in a combination of on and off states to change the bacteria’s behavior.
“E. coli is not going to want to make your biofuel at all,” said Gill, who’s also a CU-Boulder associate professor of chemical and biological engineering. “It doesn’t do that naturally. It’s programmed with thousands of genes controlling how it replicates. We’re figuring out what control structure we need to rewire in the bug to make it do what we want, not what it wants.”
Included in the team are Rob Knight, CU-Boulder associate professor of chemistry and biochemistry; Pin-Ching Maness, principal scientist at DOE’s National Renewable Energy Laboratory, or NREL; and Adam Arkin, physical biosciences director at DOE’s Lawrence Berkeley National Laboratory.
The researchers hope to engineer the production of ethylene and isobutanol in the modified E. coli. The two compounds are widely used commodities that can be converted into gasoline among other chemicals.
The greatest challenge is harnessing an efficient and inexpensive process that competes with abundant and low-cost fossil fuels like oil, according to Gill.
“Microorganisms and their genomes are incredibly complex machines,” said Gill. “The first step alone — of pinpointing the part of the E. coli genome that can help us make biofuels or other chemicals on a cost-competitive basis — is a daunting challenge. Then we have to determine if the results we want will take one year or decades, $5 million or $500 million.”
The team will be able to simultaneously identify numerous E. coli genes and the results of turning these genes on or off using advanced technologies. Many of the technologies have been developed by the researchers’ own labs.
The grant is the first of its kind from the DOE’s Office of Biological and Environmental Research and was awarded to only seven other research groups including teams led by MIT, Purdue University and the J. Craig Venter Institute.
In 2011, CU’s Technology Transfer Office named Gill an inventor of the year. In 2005, Gill won a National Science Foundation CAREER Award as well as a National Institutes of Health K25 Career Development Award for genomics research and teaching.
CU-Boulder professor inducted into American Academy of Arts and Sciences
Oct 27th
She was elected to the academy in recognition of her exceptional achievements in scientific research. Among the other 218 new members elected this year were U.S. Secretary of State Hillary Clinton, actor and director Clint Eastwood, journalist Judy Woodruff and Amazon.com founder and chairman Jeff Bezos.
Founded in 1780, the American Academy of Arts and Sciences is an independent policy research center that conducts multidisciplinary studies of complex and emerging problems. The academy’s elected members are leaders in the academic disciplines, the arts, business and public affairs.
Vaida’s research uses spectroscopy to explore different chemical reactions in the atmosphere, with many of these reactions having environmental implications. She is the 23rd CU-Boulder faculty member to be elected to the academy.
The academy’s unique strength lies in the distinguished leadership of its 4,600 fellows and 600 foreign honorary members and the wide range of expertise they bring to its multidisciplinary analyses of compelling contemporary issues.
The only other new academy member elected from Colorado this year was Mark Johnston, a professor of biochemistry and molecular genetics at CU Denver.
CIRES is a joint institute of CU-Boulder and the National Oceanic and Atmospheric Administration. To learn more about Vaida’s current research, visit her laboratory home page at http://www.colorado.edu/chem/vaidalab/index.htm.